Clinical Significance Of Serum Albumin In Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:To explore the Clinical significance of serum albumin(ALB)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods : To collect the clinical data of 141 cases of hospitalized patients with AECOPD(AECOPD group)、56 outpatient patients with chronic obstructive pulmonary disease stabilization(COPD group)、42 cases of healthy physical examination data at the same time(healthy control group),compare the amount of ALB 、 total protein(TP)、 prealbumin(PAB)between three groups.Based on the lung function GOLD classification,AECOPD patients were divided into GOLDI、GOLD II、 GOLD III、 GOLD IV,meanwhile the patients were divided into good nutritional status group 、mild malnutrition group and severe malnutrition group according to albumin level,the classification of lung function in every group was calculated.Based on the prognosis,AECOPD patients were divided into improved group and death group,compare the amount of ALB、TP between two groups,using the multi-factor Logistic regression to analysis the correlation between AECOPD patients’ age,body mass index(BMI),smoking index,TP 、 ALB and the prognosis of disease.The correction was analyzed with ALB between antimicrobial use time and the total hospitalization expense of improved group.Results:The difference of ALB and TP levels in the AECOPD group,COPD group and healthy control group was statistically significant(F=96.986,P<0.05;F=51.226,P<0.05),but PAB in the three groups were not statistically significant(F=1.331,P>0.05).It has correction between ALB and lung function classification(r=0.653,P<0.05).The difference of ALB and TP levels in the improved group and death group was statistically significant(t=4.740,P<0.05;t=3.606,P<0.05).The reduction of ALB and TP is the independent risk factors of death in patients with AECOPD(OR=0.542,95%CI : 0.370-0.795,P<0.05;OR=0.775,95%CI :0.620-0.969,P<0.05).ALB level was negtively correlated with antimicrobial use time and thetotal hospitalization expense(r=-0.796,P<0.05;r=0.-0.808,P<0.05).Conclusion The ALB can be used to evaluate the severity and prognosis of patients with AECOPD,and it also has important instruction significance for clinical treatment.