Correlation Analaysis Between Fractional Exhaled Nitric Oxide And Lung Fuction In Asthma

Background And ObjectiveBronchial asthma is a common disease with a rising annual respiratory disease and morbidity.It is a chronic inflammatory airway disease that involves the activation of many inflammatory cells and cytokines.Chronic,persistent chronic inflammation of the airways can lead to airway responsiveness.Gradually increase and airway remodeling occurs,resulting in narrowing of airway obstruction after smooth muscle spasm and airway edema.Lung function,especially forced expiratory lung volume in the first second(FEV1),is the most commonly used objective indicator for assessing asthma condition and staging.The main response to small airway ventilation function and the severity of asthma attack,but the severity of airway spasm during acute attack is not equal to the severity of airway inflammation,long-term airway inflammation is the most important one of the reasons.The essence of the treatment of asthma is to control airway inflammation,but routine clinical assessment methods do not involve accurate assessment of the severity of respiratory inflammatory responses.The treatment plan proposed by the latest GINA guidelines is still based on the clinical characteristics of patients,lung function indicators such as forced expiratory volume in one second(FEV1),The Forced expiratory volume in one second/Forced vital capacity ratio(FEV1/FVC)was adjusted.There have been several studies that have demonstrated that the correlation between clinical manifestations and lung function tests and airway inflammation is not significant,and some pulmonary function tests in asthmatic patients are normal and have no prominent clinical manifestations.The inflammatory response can still persist in the airways,which also indicates that the pulmonary function tests commonly used in clinical practice cannot accurately reflect the role of inflammatory reactions in the airway.Therefore,we need to look for an indicator that can monitor and evaluate asthma condition control and inflammation in the early stage so that we can accurately tell patients the severity of illness and guide their treatment in the early stages of bronchial asthma.As a new type of airway inflammation assessment method,FeNO detection has attracted more and more attention and research.This article is to FeNO detection as a starting point to explore the correlation between FeNO level and lung function before and after treatment of bronchial asthma patients to analyze the clinical application value of FeNO.Materials And MethodsFrom September 2016 to November 2017,bronchial asthma patients attending the First Affiliated Hospital of Zhengzhou University selected patients who met the selection criteria.100 patients with bronchial asthma diagnosed in the clinical diagnosis and past history were included as asthma cases.The group(aged 15-69 years,44 males,and 56 females)had diagnostic criteria that met the Global Initiative for Asthma(GINA)2017 and the “Bronchial” of the 2016 Chinese Medical Association Respiratory Society Asthma Group.Asthma Prevention Guidelines" standard.At the same time,50 healthy people of the same age group from the First Affiliated Hospital of Zhengzhou University were selected as the control group(age 20-65 years old,27 men and 23 women).This article mainly analyzes whether there is statistical difference between FeNO level and lung function indicators and healthy control group in bronchial asthma group,and compares whether FeNO level and lung function index are measured before and after treatment with salmeterol.There is a linear correlation.ResultsThere was no significant difference in age,gender,height,weight,and smoking history between the bronchial asthma group and the healthy control group(P>0.05).The level of FeNO in patients with bronchial asthma before treatment was higher than that in healthy controls(P<0.05),and the ratio of forced expiratory volume in one second before treatment in bronchial asthma patients group(Forced expiratory volume in one).The second/predicted value ratio(FEV1%pred)and the ratio of Forced expiratory volume in one second/Forced vital capacity ratio(FEV1/FVC)were all lower than those in the control group.Significance(P<0.05);3 months after treatment with salmeterol,the FeNO index was higher in the bronchial asthma group than in the control group(P<0.05).After treatment,the bronchial asthma group was treated with FEV1% pred.The index was lower than the control group,the difference was not statistically significant(P>0.05).After treatment,the FEV1/FVC index in the asthma group was lower than that in the control group,and the difference was statistically significant(P<0.05).After the treatment of asthma with salmeterol for three months was higher than before treatment,the difference was statistically significant(P<0.05).After the treatment of asthma,the FEV1% pred index was higher than that before treatment,the difference was statistically significant.Significance(P<0.05).The FEV1/FVC index of the patients with asthma treated with salmeterol was significantly higher than that before treatment(P<0.05).The level of FeNO before treatment in the asthma group was negatively correlated with the FEV1%pred before treatment(r=-0.546,P<0.05).There was a negative correlation between the FeNO index before treatment and the FEV1/FVC before treatment.(r=-0.506,P<0.05).There was no significant correlation between FeNO level and FEV1% pred index after treatment of salmeterol at 3 months(r=-0.182,P>0.05);asthma patients were treated with salmeterol FeNO levels were no significant correlated with FEV1/FVC index after treatment(r=-0.166,P>0.05).Conclusion1.Monitoring FeNO values can sensitively reflect the status of inflammation control.It can quickly reflect the effect of drug treatment in the treatment of asthma.It can be used as an indicator to evaluate the therapeutic efficacy of bronchial asthma.2.FeNO levels in untreated asthma patients were significantly negatively correlated with FEV1% pred and FEV1/FVC in lung function.FeNO levels after treatment were not correlated with FEV1% pred,FEV1/FVC in pulmonary function,and FeNO was comparable to lung function.Having a higher sensitivity can partially replace lung function in the management of asthma patients,so combining the two can better control the condition.