Study On The Prevalence And The Influence Factors Of The Metabolic Syndrome In The Jinchuan Occupational Cohort

Objective:To assess the prevalence of metabolic syndrome(MS,Chinese Diabetes Society diagnostic criteria)and its related components in the Jinchuan occupational cohort,in Gansu Province,China.To explore the influence factors of MS in the different sexes.To provide basic data and scientific data for the planning MS prevention measures of the MS in occupational groups.Methods:This study were cross-sectional study and case-control study based on the beginning building of the Jinchuan occupational cohort.Epidemiological survey data and both physiological and biological data were collected from workers in Jinchuan occupational cohort between June 24,2011 and September 28,2012.The epidemiological survey data included general demographic characteristics,behavioral characteristics,history of occupational exposure,medical history,family history of chronic disease and female physiological and reproductive history.The physiological and biological data included height,weight,blood pressure,and the level of some serum biochemical indicators.The data were used to calculate the prevalence of MS,and logistic regression,principal component analysis and factor analysis were used to identify the influence factors of MS in the different sexes.Results:1.The prevalence and adjusted prevalence of MS in the Jinchuan occupational cohort were 11.44%and 11.72%,respectively,and the prevalence of MS in males and females were 15.27%and 4.90%,respectively.The prevalence of MS in males was significantly higher than that in females(P<0.05).The prevalence of components related to MS(from high to low)were 42.84%for high triglycerides(H-TG),27.45%for overweight/obesity,25.98%for high blood pressure(HBP),12.69%for high blood glucose(HBG)and 6.96%for low-High density lipoprotein-cholesterol(L-HDL-C).The prevalence of L-HDL-C was significantly higher in females than in males(P<0.05),while the prevalences of H-TQ overweight/obesity,HBP,and HBG were significantly higher in males than in females(P<0.05).2.The prevalence of MS increased with age in the Jinchuan occupational cohort,and was highest in 70+ age group(23.31%).And the prevalence of MS increased with age for both sexes in the Jinchuan occupational cohort,and were highest in 70+ age group(in males and females were 23.39%and 22.62%).The prevalence of MS in the 20-29,30-39,40-49 and 50-59 age groups were significantly higher in males than in females(P<0.05),but did not differ significantly between the sexes in the 60-69 and 70+ age groups.The prevalences of components related to MS in females all increased with age,and the prevalences of HBP and HBG in males increased with age as well.Except for HBG and L-HDL-C,the prevalences of components related to MS in the 20-29,30-39,40-49 and 50-59 age groups were significantly higher in males than in females,but did not differ significantly between sexes in the 60-69 and 70+ age groups.3.The prevalences of coronary heart disease,stroke,fatty liver,gout,and gallstones in MS patients(cases)were significantly higher than those in the normal metabolic group.The levels of serum uric acid(SUA),high sensitivity C reactionprotein(hs-CRP),apolipoprotein B(ApoB),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),aspartate transaminase(AST),creatinine(CREA)and blood urea nitrogen(BUN)in cases were significantly higher than that in the normal metabolic group,after age and gender matched,the difference between cases and controls remains.4.The risk factors for MS in males were Han or Manchu ethnicity(compared to the Mongol ethnicity);office or indoor work(compared to workers);smoking;drinking;family history of hypertension or diabetes mellitus;and high levels of SUA,CREA,hs-CRP,ApoB,TC,LDL-C,ALT and AST.Risk factors for MS in females were workers or indoor work(compared to technicians);family history of hypertension or diabetes mellitus;menopause;and high levels of SUA,BUN,CREA,ApoB,TC,ALT,and AST.Protective factors for MS in females were high level of education,and moderate alcohol consumption[the median±quartile of drinking index(DI)were 8.401±19.56(50g year)].Conclusion:1.The prevalence of MS in the Jinchuan occupational cohort was higher than the national average.The prevalences of MS in males and in 50+ year old females were especially high,so those risk groups should be actively targeted for public health education and preventive care.2.H-TG and overweight/obesity were the main components of MS in the Jinchuan occupational cohort.3.There are close relationships between MS and coronary heart disease,stroke,fatty liver,gout,and gallstones.Those comorbid conditions should be the focus of public health interventions.At the same time,there were also close relationships between MS and SUA,BUN,and CREA,which suggests that MS may correlate with chronic renal disease.4.The risk factors for MS in males and females were different.The prevalence of MS is higher in males mainly because of their behaviors(smoking and drinking).After 50 years of age,the prevalence of MS in females increases quickly with age,and was not significantly different between both sexes in the 60+ years old mainly because of menopause,obesity becouse of menopause,and changes in sex hormone levels in females.Based on the risk factors for MS in the different sexes,appropriate measures should be taken to reduce the prevalence of MS and to alleviate the harm of cardiovascular and cerebrovascular diseases in workers of the Jinchuan occupational cohort.