Synthesis Of Bipyridine Compounds And Catalysis Of Amino Acid Salts Analysis Of Aldol Reaction

Due to its similar structure to benzene,pyridine also has a certain aromaticity.The chemical reaction with its raw materials or intermediates is a hot topic in chemical analysis and synthesis research.The main substrate 2-acetyl group used herein is a derivative of pyridine which is a transparent,colorless or slightly brown liquid at normal temperature,and is contained in chemical or daily-use flavors.Therefore,it has been of great interest to explore a method for directly synthesizing a bipyridine compound with a simple reaction substrate and a mild reaction condition.In view of the above research status,this thesis contains the following two aspects: This paper mainly introduces the reaction of 2-acetylpyridine with two different substrates,and synthesizes two different compounds of bipyridine and pyridone.(1)Bipyridine compounds: These compounds can be used as bidentate ligands in asymmetric synthesis compounds,which play a very important role in organic pharmacological research.At present,the most important idea for chiral organic chemistry is to obtain optically pure products by asymmetric catalysis.The choice of catalysts and solvents is particularly important.Most of the traditional methods of synthesizing such compounds use the concept of organic synthesis,but the solvents of this type of reaction are mostly organic solvents,and their toxicity and difficult to recycle characteristics will pollute the environment.In recent years,green synthetic chemistry has emerged.This paper replaces traditional organic solvents with high-purity water and directly synthesizes a class of bipyridines without using a catalyst.The reaction explored in this paper is one of the Aldol reactions and belongs to green.The scope of chemistry.16 kinds of bipyridines were synthesized by using different conditions such as reaction time,reaction temperature and equivalent ratio without using a catalyst,using 2-pyridinecarboxaldehyde and 2-acetylpyridine as template.The resulting product was characterized.The maximum significance of this experiment is twofold: 1.This is a method of green chemistry.2.The obtained product can be used as a ligand by complexing with a metal cation.(2)Pyridone compound: Based on the previous research on natural amino acid salt,I discussed its application in Aldol reaction.The product was synthesized by a one-step Aldol reaction using acetone and 2-acetylpyridine as raw materials and L-methionine as a catalyst,and the product had a certain optical purity.This reaction provides another idea for the asymmetric Aldol reaction,further enriching the application of amino acid salts in the field of asymmetric catalysis.The significance of this experiment has two points: 1.The cheap and easily available amino acid salt has the ability to catalyze the reaction 2.For the first time,the enantioselectivity of the two substrates in the experiment under the catalysis of amino acid salt is achieved.