Study On CBr₄ Promoted Oxidative Dehydrogenative Coupling Reaction Of Amines

This thesis depicts the author's graduate research works which have been focused on CBr₄ promoted oxidative dehydrogenative coupling reaction of amines and stable radical cation salt initiated N-H insertion and related proton-transfer-delay three-component reaction. It comprises four parts. in the first part, the recent progresses made on applying no- metallic reagent C Br₄ in organic synthesis is briefly reviewed. The second part and the third part, fourth part deal with the author's own researches which are summarized as following:?1? A novel CBr₄-mediated dehydrogenative Povarov/aromatization tandem reaction of glycine derivatives with alkenes, leading to complex quinoline derivatives, and a CBr₄-mediated dehydrogenative C-H functionalization of N-aryl tetrahydroisoquinolines with nucleophiles to form C-C and C-P bonds.?2? CBr₄ promoted dual-oxidative dehydrogenative cyclization of glycine derivatives with dioxane under solvent free aerobic conditions, which deliver complex cyclic frameworks.?3? The stable radical cation salt initiated insertion of diazoacetates into anilines' N-H bonds, the reaction of anilines with both diazoacetates and azodicarboxylates in the presence of catalytic amounts of triarylaminium salt gives the corresponding complex unsymmetrical aminals in high yields. This is the first example of stable radical cation salt promoted proton-transfer-delay three-component reaction.