| Objective:Polycystic ovary syndrome is one of the most common endocrine and metabolic disorders in women at childbearing age.It is also a major cause of menstrual disorders and infertility for women.The most common manifestation of menstrual disorders is menstrual sparseness and small amounts.Modern medicine mainly uses oral contraceptives for the treatment of PCOS in late menstruation.Although it is effective in the short term,many studies have shown that the long-term efficacy is poor,and adverse reactions and side effects are easy to occur.This study compared the changes of menstrual cycle,volume,color,meridian,dysmenorrhea,TCM syndrome scores,sex hormones,gynecological color ultrasound changes long-term recurrence rate and pregnancy rate return visit,before and after the treatment of tonifying kidney and removing blood stasis medication in the late menstrual period..Explore the clinical efficacy and safety of tonifying kidney and removing stasis method in the treatment of polymensary ovary syndrome in the late menstrual period,and preliminary analysis of its mechanism of action,will further provide feasible ideas,effective methods and reliable clinical basis for the treatment of polycystic ovary syndrome.Methods:In this study,42 cases in total that meet the diagnostic criteria were included.They were all given to the advisor of tonifying kidney and removing stasis treatment..They began to be taken on the 5th day of the menstrual period.This cycle was repeated.The 3-month menstrual cycle was used as a course of treatment,and then the menstrual cycle was observed as well ascolor,amount,quality,dysmenorrhea,the TCM syndrome scale,sex hormones,and gynecological color ultrasound changes.After the withdrawal of 3 menstrual cycles,a telephone callback was conducted.The clinical data collected were entered into an Excel spreadsheet,a database was established,and SPSS20 statistical software was used for data analysis.Result:(1)The method of tonifying kidney and removing blood stasis can significantly shorten the menstrual cycle of patients with polycystic ovary syndrome in the late menstruation,and significantly improve the amount,color,quality,and dysmenorrhea of the patients.(2)The method of tonifying kidney and removing blood stasis can improve the symptoms of systemic kidney deficiency and blood stasis syndrome besides dizziness and tinnitus.(3)The method of tonifying kidney and removing blood stasis can significantly reduce the ratio of luteinizing hormone,luteinizing hormone and follicle stimulating hormone,and there is no significant change in androgen and follicle stimulating hormone before and after treatment.(4)The method of tonifying kidney and removing blood stasis can significantly improve the thickness of the endometrium and the diameter of the largest follicle,but there is no significant effect on the change of the ovarian volume.(5)The method of tonifying kidney and removing blood stasis can significantly reduce the weight of patients and improve acne problems in patients;but there is no obvious effect on the improvement of hairiness in PCOS patients.(6)During the treatment period,none of the patients had any adverse events.It also showed that tonifying kidney and removing blood stasis method is a safe and reliable method for treating PCOS in the late menses.(7)Three months after discontinuation,one case of pregnancy was present and no relapse occurred.Conclusions:(1)tonifying kidney and removing blood stasis medication may regulate the hypothalamus-pituitary-ovarian axis,gradually increase the endometrium,promote follicular development,regulate hormone secretion,in order to restore the menstrual cycle and promote ovulation.(2)tonifying kidney and removing blood stasis medication also indirectly verified that kidney deficiency and blood stasis symptoms is one of the common syndromes in the late menstrual period of polycystic ovary syndrome,confirms the feasibility of the theory of qi and essence inter-transformations for treating PCOS and kidney deficiency and blood stasis symptoms. |
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