| Objective To synthetically evaluate the effects of vitamin D supplementation on fasting blood glucose,glycosylated hemoglobin,insulin resistance,β cell function in type 2 diabetes mellitus,and to provide the basis for vitamin D replenisher to control blood glucose in patients with type 2 diabetes mellitus.Methods Databases including The Cochrane Library(Issue 12,2015),Pub Med,Web of Science,Science Direct Online,VIP,CNKI,Wan Fang Data,and CBM were searched to collect randomized controlled trials(RCTs)about vitamin D supplementation for type 2diabetes mellitus from inception to December 2015.Two reviewers independently screened literatures,extracted data and assessed the risk of bias of included studies.Then meta-analysis was conducted by Rev Man 5.3 and Stata12.0 softwares.Results A total of 19 articles were included(Because two RCTs were included in three articles,a total of 22 RCTs were included).1756 patients were included(889 patients in experiment group,867 patients in control group).The results of meta-analysis showed that,compared with the control group,the vitamin D supplementation group had a significant improvement in insulin resistance(SMD= – 0.68,95%CI –1.23 to – 0.12,P=0.02),but there were no significant differences in levels of FPG,Hb A1 c and HOMA-β between the two groups(all P value >0.05).Subgroup analysis were done according to race,gender,BMI,and so on.It showed that,the levels of FPG and HOMA-IR were significantly decreased in the vitamin D supplementation group in Middle Easterners and patients whose follow-up duration was less than three months.ConclusionsThe evidence shows that vitamin D supplementation improves HOMA-IR but does not improve FPG,Hb A1 c and HOMA-β.However,the evidence is weak to recommend vitamin D as a means of improving glycemic control,insulin resistance and β cell function in type 2 diabetes mellitus.Further larger,high quality trials are warranted.Objective In order to provide a reference for preventing and curing type 2 diabetes by exploring the correlation of vitamin D intake and glucose control.Methods200 inpatients with type 2 diabetes mellitus in X third-class hospital were selected as test group by convenience sampling.The control group is composed of 200 healthy cases in the same period.Surveys of dietary status every day and were conducted in the subjects with 24 h retrospective method one day before treatment.Food frequency inquiry method was used to understand the intake frequncy of vitamin D dietary and supplementation in patients a month period.The intake status of vitamin D every day and the frequency of vitamin D dietary a week in one month were calculated.And the correlation analysis was done among age,body mass index,blood lipid,blood pressure,the time for outdoor activities,the intake status of vitamin D every day among glycosylated hemoglobin.To analyze the relationship between glycemic control and the relevant variables by Logistic regression.Results The intake status of vitamin D every day in patients with type 2 diabetes mellitus was lower than the control group whose average status(202.86±85.87 IU,282.55±59.80IU).There was significant difference between two groups(P<0.05).And the intake frequency of vitamin D and supplementation in patients was lower than the frequency of the control group.Correlation analysis showed that factors affecting glycemic control in patients with type 2 diabetes include: the course of diabetes,triglycerides,total cholesterol,High Density Lipoprotein,Low Density Lipoprotein,vitamin D intake every day(r=0.278,0.339,0.254,-0.457,0.219,-0.151;P<0.05).Patients in standard-reaching group and patients in non-standard reaching group were significantly different in triglycerides,total cholesterol,High Density Lipoprotein,vitamin D intake every day(P<0.05).Logistic regression showed that factors affecting glycemic control in patients with type 2 diabetes include: total cholesterol,High Density Lipoprotein,vitamin D intake every day(B=0.581,-1.921,-0.006;P<0.05).Conclusions Because of the limitations of the disease,the amount of vitamin D intake was insufficient in patients with type 2 diabetes mellitus.And the intake status of vitamin D every day in patients with type 2 diabetes mellitus was lower than that in the control group.And there was a relationship between the intake status of vitamin D every day and glucose control.Therefore,the deficient intake of vitamin D could be the cause of blood glucose evaluation in patients with type 2 diabetes mellitus. |
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