| [Objective]To explore the relationship between thyroid function and early threatened abortion and the relationship between thyroid function and outcome miscarriage;To summarize the syndrome distribution of TCM of the early threatened abortion patients and plus hypothyroidism on preliminary levels.[Method]We have done retrospective collection of clinical data of the patients suffering from early threatened abortion in gynecology of the affiliated hospital of Chengdu University of TCM from March 2014 to February 2015.149 cases have been grouped into euthyroidism, hypothyroidism and hyperthyroidism in accordance with inclusive and exclusion criteria. All the data has been analyzed on the platform of SPSS 18.0 statistical software. The research mainly focuses on the relation between early threatened abortion and thyroid function. There are 29 plus resistance to insulin cases among 85 euthyroidism cases and 30 plus resistance to insulin cases among 61 hypothyroidism cases.[Result]1.Among 149 cases of patients suffering from early threatened abortion, there are 85 (57.05%) patients with euthyroidism,61 (40.94%) patients with hypothyroidism, 3(2.01%) patients with hyperthyroidism. No statistical analysis has been conducted on the very limited hyperthyroidism cases.2.There is no statistical significance in taking the differences in terms of age, height, weight, body mass index (BMI), abnormal pregnancy and delivery history, pregnancy and delivery history, habitual abortion history, islet function test, plus PCOS, menstrual cycle, quality and volume into account (P>0.05).3.There is no statistical difference in 4 to 10 weeks of serum E2, P, P-HCG (P> 0.05).The values of E2, P, β-HCG of the two groups increased with gestational weeks going on.There is no statistical difference in miscarriage outcome (P>0.05).4.The relationship between TSH level and tocolysis outcome is statistically significant (P<0.05).There are 46 cases whose TSH values are between 2.5-5 mIU/ L, of which 10 cases have failed in tocolysis (21.74%); 10 cases whose TSH values are between 5-7mIU/L, of which 4 cases have failed in tocolysis(40%); and 5 cases whose TSH values are beyond 7mIU/L, of which 4 cases have failed in tocolysis (80%).5. It is statistically significant in comparing the TPOAb positive rate differences between the two groups (P<0.05). However, there is no statistical point in comparing the TPOAb positive rate with tocolysis outcome (P> 0.05).There is statistical importance in focusing on the comparison between the TPOAb positive rate and the number of previous abortions (P<0.05).6.Patients of both groups are mainly characterized with normal facial color, pink tongue, thin white fur as well as weak and slippery pulses.The common TCM symptoms of the euthyroidism group are as follows:sore and pain in loin and legs, irritability, tastelessness, abdominal pain, feeling dry and thirsty, dizziness and tinnitus and being physically and mentally fatigued, etc. Sore and pain in loin and legs as well as irritability are mostly frequently witnessed. The common TCM symptoms of the euthyroidism group are as follows:sore and pain in loin and legs, irritability, tastelessness, abdominal pain, feeling dry and thirsty, dizziness and tinnitus and being physically and mentally fatigued, etc. Sore and pain in loin and legs as well as irritability are mostly frequently witnessed. The ordering and common TCM syndrome are kidney deficiency syndrome(17 cases),10 cases in kidney deficiency syndrome,spleen and kidney deficiency syndrome(13 cases),kidney deficiency and liver depression with blood stasis syndrome(11 cases) in normal thyroid function group; The ordering and common TCM syndrome are deficiency syndrome(12 cases),8 cases in the deficiency syndrome(66.67%),spleen and kidney deficiency syndrome (8 cases) and Qi and blood deficiency syndrome(8 cases) in hypothyroidism group.[Conclusion]1.The number of plus hypothyroidism patients is the highest among 149 patients suffering from early threatened abortion.2.This study preliminary depicts that that there is no statistical importance in comparing the tocolysis outcome difference between hypothyroidism patients after treatment and euthyroidism patients. In other words, levothyroxine sodium tablets eliminate the tocolysis outcome differences.3.It can be concluded from the research that there are no remarkable changes to serum E2, P and β-HCG values from 4 gestational weeks to 10 gestational weeks after hypothyroidism patients are on medical treatment.4.The rate of tocolysis failure increases with TSH level in hypothyroidism group.5.The TPOAb positive rate of hypothyroidism group is remarkably higher than that of euthyroidism group, but the effect of TPOAb positive rate does not have an obvious influence tocolysis outcomes of the two groups. The previous total abortion≥ 2 times with the positive rate of TPOAb is higher than≤1 time.6.There are no obvious differences between the two groups in terms of facial complexion as well as tongue and pulse presentation. Both groups are mainly characterized as kidney deficiency. Sore and pain in loin and legs are most frequently witnessed, besides, hypothyroidism patients suffer from insufficiency with chills as well as being physically and mentally fatigued more. |
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