Analysis Of The Types And Drug Resistance Of Bloodstream Infection Pathogens In Patients With Malignant Hematological Diseases In Gaomi City People's Hospital

Objective: To analysis the pathogenic bacteria and antibiotic resistance in bloodstream infection patients with malignant hematological disease in our hospital, and to explore their clinical characteristics and the related factors in order to provide rational experimental reference for clinical prevention and treatment.Methods: A retrospective analysis was made on clinical data, separated pathogenic bacteria types, antibiotic resistance and characteristics in 121 patients complicated with bloodstream infection among 1005 clinical hematologic malignancies patients in the Department of Hematology, Gaomi City people’s hospital.Result: Among the 1005 patients, the incidence of bloodstream infection was 12.04%, which was dominated by acute lymphoblastic leukemia(26.4%),acute myelogenous leukemia(19.8%),malignant lymphoma(14%).lung and upper respiratory were most common in bloodstream infections, accounted for 24.8% and 21.5% respectively.74 cases(74 strains) blood culture samples were positive. Gram-positive bacteria were 40 strains, accounting for 54.1%, Gram-negative bacteria were 31 strains, accounting for 41.9%, fungi were 3 strains, accounting for 4.1%. The top three pathogens were Staphylococcus epidermidis(20.3%), Escherichia coli(16.2%) and Klebsiella pneumoniae(16.2%).Antibiotic susceptibility test results showed that Staphylococcus was highly sensitive to vancomycin and linezolid, and was resistant to clindamycin, penicillin, erythromycin and trimethoprim sulfamethoxazole and Escherichia coli and Klebsiella pneumoniae was highly sensitive to Cefoperazone/sulbactam and imipenem and was resistant to cefazolin, cefuroxime, spore ceftazidime, Cefpiramide, ampicillin and Cefradine cefotaxime.Conclusion: Gram positive bacteria were the main pathogenic bacteria for bloodstream infection patients with malignant hematological disease in our hospital, and were resistant to most antibiotics. Therefore, it is essential for correct antibiotics application based on early drug resistance detection for bloodstream infection patients.