| Biomedical materials, also known as biomaterial, could be used for tissue and organ repair or substitution and disease diagnose and therapy. Polymer and its composite material is the most widely used biomedical material. Blood filter material, in direct or indirect contact with human body, aiming at the removal of harmful components or ingredients, has important application in the artificial kidney (renal dialysis), artificial liver, artificial lungs, leukocyte filter, platelet filter and other new medical devices. Currently, the biocompatibility of blood filter material is a key factor that determines their clinical application and an active research area in both academia and industry.In order to improve the wettability and biocompatibility of polyethylene terephthalate non-woven fabric (PBTNW) and polypropylene non-woven fabric (PPNW),this study take grafting and coating methods.The product is thoroughly characterized with Fourier transform infrared spectroscopy (FTIR), electron spectroscopy for chemical analysis (ESCA), thermogravimetric (TG), scanning electron microscopy (SEM) and water contact angles. It is found that the monomers are successfully modificated onto PBTNW or PPNW and the wettability is deeply improved. In addition, coagulation tests, plasma recalcification time (PRT), hemolysis tests, platelet and fresh human whole blood adhesion tests, complement activation, platelet activation, and cytotoxicity evaluation tests show an improvement in biocompatibility.The results show that the monomers(CS/Hep/Betaine) are successfully modificated onto PBTNW or PPNW and the wettability and biocompatibility is deeply improved.The major findings of this paper are as follows:1.The study of CS grafting PBTNWChitosan is popular in the field of biomedical applications due to its satisfactory biocompatibility and biodegradability. It’s widely used in biomedical applications for tissue engineering, medical devices, health care, including the case in which the polymer surface is in direct contact with blood. When the chitosan contact with the blood, it plays a hemostatic role in wound because of the blood coagulation. But the effect of blood coagulation could change into the anticoagulated effect when the chitosan is modifited by a certain method. Herein, we reported a conventional and useful method for chemical modification using chitosan(CS), which acts as a hydrophilic modifier of polyethylene terephthalate non-woven fabric (PBTNW) surface by using graft polymerization.The modified material using copolymerization-grafting method was characterized through ATR-FTIR, ESCA, TG, water contact angle test, and CWST. All the results proved that the monomer was grafted onto the substrate. Biocompatibility experiments on grafted substrate, such as hemolysis assay and platelet adhesion tests, were also conducted. The results suggested that the grafted substrate had achieved the international standard.2.The study of CS and Betaine coated PPNWBetaines with both cationic and anionic groups on the same monomer residue, including phosphorylcholine, sulfobetaine and carboxybetaine,have received considerable interest as regards their chemical, biological and medical applications, since they are extremely effective in reducing protein adsorption, platelet adhesion and activation, and thrombus formation in vitro. In the study reported here, we prepared a polypropylene non-woven fabric (PPNW) modified with betaine and CS, using coating method. The physical characteristics and biocompatibility experiments show that the modified material have a good hydrophilicity and biocompatibility.3.The study of CS and Hep coated PPNWAs we all known, heparin has a good anticoagulated effect. In the study reported here, we prepared polypropylene non-woven fabric (PPNW) modified with heparin and CS using the method of coating. The physical characteristics and biocompatibility experiments show that the modified material have a good hydrophilicity and biocompatibility. |
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