Cervical cancer(CC) is one of the most common malignant tumor in women.The main therapy of early stage CC is radical hysterectomy(RH),but after surgery often be complicated by urinary retention,which may seriously affect the quality of life of the patients. Therefore, the prevention and treatment of urinary retention after RH has important clinical significance.This study is divided into three parts:1.Modified operation application of evidence-based medicine method to alleviate postoperative complications after RH, namely nerve-sparing radical hysterectomy(NSRH) and provide the basis for the efficacy and safety. 2.Through the case study on traditional Chinese medicine Wulingsan for clinical analysis of urine retention prevention after RH. 3. To review the common complications after RH. Summary the prevention of postoperative urinary retention of RH,treatment method and effect of traditional Chinese medicine and Western Medicine in recent years.Evidence-based medicine for the efficacy and security of NSRH in reducing postoperative complications of cervical cancerPurpose : To estimate the efficacy and security of NSRH in reducing postoperative complications of cervical cancer.Material and method:Large databases were searched in recent 11 years for studies which were prospective controlled trials comparing clinical efficacy of NSRH with that of RH in treating cervical cancer. A comprehensive quantitative analysis was performed by Meta-analysis method.Results:Meta-analysis results showed that the pooled WMDs values of cervical cancer for the highest versus lowest of Indwelling catheter time levels were-6.73,95%CI-7.39~-6.06;the time of residual urine volume <50 m L levels was-7.80,95%CI-11.93~-3.67;the first exhaust time was-12.05,95%CI-15.87~-8.24;the first defecation time was-24.99,95%CI-26.87 ~-23.11;days of hospitalization were-4.00, 95%CI-4.60~-3.40;uterine resection length was-0.10,95%CI-0.15~-0.06;these all significantly reduced.The total operation time was 30.74,95%CI 16.66 ~ 44.82,which was lengthened. No significant differences were found in the number of lymph nodes, bleeding volume, postoperative overall recurrence rate.Results: 1.NSRH early cervical cancer can shorten the recovery time of bladder function, recovery time of intestinal function and hospitalization time in treatment of early stage cervical cancer.2.According to the present studies,NSRH is safe and feasible,but still need to provide evidence for higher quality clinical studies.Clinical study on treatment of cervical cancer of urinary retention after radical operation of WulingsanPurpose:To investigate the factors related to urinary retention and the effect of the treatment of traditional Chinese medicine and Western medicine to urinary retention after RH operation.Material and method:Statistics the information of early CC cases treated with surgical treatment in Liaoning Cancer Hospital during January 2012 to January 2014, analysis of patient age, preoperative complications, clinical stage, pathological type, postoperative complications and other data. A total of 150 patients accepted RH operation treatment.41 cases of urinary retention after the operation, the application of traditional Chinese medicine Wulingsan in treating 18 cases of patients, 23 cases of simple western medicine treatment,analysis of therapeutic effect of two groups.Results: 1.To compare the two groups of patients in age, preoperative complications, clinical stage, pathological type, operation and other data, there was no significant difference(P>0.05).2.Chinese medicine Wulingsan curative effect in treatment group was higher than that of the control group, there were statistically significant differences in the treatment effect of the two groups(P<0.05).3.There were no obvious differences in adverse reactions between the two groups(P>0.05).Conclusion: 1.Traditional Chinese medicine Wulingsan have certain curative effect for the treatment of urinary retention, which after radical hysterectomy of cervical cancer.2.Oral Wulingsan is well tolerated, no obvious side effects. |