Design,Fabrication Of Non-planar Microfluidic Chips And Double Emulsion Droplets Generation

Microfluidic chip is an important branch of lab on a chip technology.After developed for decades,microfluidic chip has grown to be an integrated research platform in the fields of physics,biology,pharmacy and MEMS etc.The design and development of microfluidic device always grab attentions.Because of the limitation of MEMS process technology and many other problems,the present technology merely focus on 2D architectre of microchannels.Hence,developing a creative and efficient design of microfluidics device by studying the chip design principle and fabrication technology will facilitate its applications on many fields.In this paper,we studied the development situation of microfluidics,especially about its development on droplet microfluidics.By studying the flow dynamics in microfluidic channels,we improved our former planar chips.Base on the former studies,we designed the non-planar device for double emulsion droplet generation,which shows great potential and reliability on double emulsion generation.Besides,we investigated and improved the fabrication process of microfluidic device.To meet the requirement of simplifying microfluidic device,we designed two different devices that both of them can be fabricated without super clean room or specific instruments.We introduced the fabrication technology and provide experiment evidence to verify their functions.In this paper,double emulsion droplet and microbubble generation experiment were implemented by non-planar devices.The non-planar device performed great reliability and stability.The co-efficient vibration can be controlled below 1.5%,implying its monodispersity.To test the ultrasonic imaging feasibility of double emulsion microbubbles,ultrasound contrast imaging experiment was implemented on mouse,which showed great potential on clinical application.