Quantitative Study Of Aorta In Healthy Adult And Hypertension Patients By 64 Multi-detector CT During Cardiac Cycle

Objective: 64 multi-detector spiral CT was used to quantitatively measure the thoracic aorta’ diameters in healthy adult and patients with hypertensive,then calculating the ratio of main pulmonary artery toaortic diameter,analyzing its correlation with cardiac cycle,age,gender,and grade of hypertension.Methods:168 patients with hypertension were included in the experimental group,229 healthy adult as the control group.All of them were treated cardiac coronary CTA scanning with 64-slice spiral CT and retrospective electrocardiography-gated.The original images of multi-periods were reconstructed in all subjects,measuring their diameter lines in systolic phase(30%)and diastolic phase(70%)and obtaining their the ratio of main pulmonary artery to aortic diameter.Results:1 In the healthy adult,the diameters of the systolic were larger than that of the diastolic(P<0.05),but no significant difference in the ratio of main pulmonary artery to aortic diameter(P>0.05).2 In the healthy adult there was also no significant correlation between the diameter of the middle part of the aortic valve annulus,aortic sinus and the diameter of the sinus canal junction(P>0.05).However the ascending aorta,descending aorta,main pulmonary artery and the ratios were significantly correlated with age(P<0.05).The diameters of the aorta in the elderly group were larger than that in the non-elderly group,while the ratios were opposite.3 The diameters of the aorta in male were higher than female(P<0.05),but rPA of the female were larger than the men.4 In both systolic and diastolic periods,there were a larger of thediameter lines in hypertensive subjects compared with the healthy(P<0.05),but rPA of the healthy were larger than the hypertensive patients.5 In both systolic and diastolic periods,there was no statistically significant difference in the diameters of the aortic sinus and sinus junction between the healthy subjects and the Grade1 hypertensive,between the Grade2 and Grade3 hypertensive patients(P>0.05).There was no significant difference in the diameter of primary pulmonary artery between the healthy persons and the Grade1 hypertensive patients and still no significant difference in the diameter of descending aorta between the Grade2 and Grade3 hypertensive patients(P>0.05).But there was obvious difference in the rest diameters of primary pulmonary artery and rPA in each group and with the rising of the grades of hypertension(P<0.05),the diameters of aorta were gradually increased,moreover the degree of vasodilation of primary pulmonary artery was relatively smaller than that of aorta,so rPA could gradually decreased with the rising in hypertension grading.6 Respectively comparing between different age groups,there was also no significant difference among their diameters of the aortic annulus,the aortic sinus and the sinus canal junction in healthy and control groups(P>0.05).There was a significant difference among the diameters of the ascending aorta,descending aorta and main pulmonary artery in both systolic and diastolic periods(P<0.05),and with the increase of age,the differences gradually decreased.7 Comparing control group with hypertension group and different hypertension groups,there was a significant difference in the diameter between the ascending aorta and the descending aorta(P<0.05),and with the increase of the grade of hypertension,the difference decreased gradually.There was also no significant difference among their diameters of the aortic annulus,the aortic sinus and the sinus canal junction in grade2 and grade3groups(P > 0.05).There was also no significant difference among their diameters of main pulmonary artery in control and hypertension group,grade1 and grade2,grade2 and grade3(P>0.05).Conclusions:1 Eelectrocardiographically gated 64 multi-detector computed tomography can obtain the data of regular diastole and systole of the aorta accompanied with the cardiac pulsation during cardiac cycle.2 The aortic diameters,main pulmonary artery diameter and the ratio demonstrated a high inter-individuaI variability and cardiac cycle dependency.3 The hypertensive patients’ diameters,both systole and diastole,were significantly larger than the diameters of the healthy adult’s diameters;while the ratio of main pulmonary artery to aortic diameter,both systole and diastole,were smaller in the hypertensive patient’s than the healthy people’s.4 Aortic root diameter in systole and diastole difference is not affected by age,but the ascending aorta,descending aorta and the main pulmonary artery in systolic and diastolic diameter difference is affected by age,ascending aorta,descending aorta and main pulmonary artery in systolic and diastolic diameter difference gradually decreased with the increase of age.5 The data of regular diastole and systole of the aorta obtained with Eelectrocardiographically gated 64 multi-detector computed tomography can objectively reflect of the average level of blood pressure in patients with hypertension.In order to screen and diagnosis of aortic diseases in hypertensive patients as early as possible,In order to detect abnormalities as soon as possible,start to treatment as soon as possible,thus avoiding the progression of the lesion and even involving other tissues and organs.