Clinical Analysis Of 231 Cases Of Chronic Atrophic Gastritis

Objective:To investigate the clinical features of chronic atrophic gastritis(CAG),including general data,clinical symptoms,laboratory tests,endoscopic and biopsy,epidemiology,diagnosis and treatment,to assist clinicians in deepening Knowledge of the disease and the level of diagnosis and treatment.Methods:A total of 231 cases of CAG diagnosed by gastroscope and pathological biopsy between January 2012 and December 2017 in Department of Gastroenterology,,First Hospital of Lanzhou University were retrospectively analyzed.According to their age,they were divided into three groups:the young group(57 cases),middle-aged group(95 cases),elderly group(79 cases).Result:1.In this study,231 patients with CAG were aged between 18 and 87 years old,with an average age of 58.62±19.31 years old.The incidence of peak age of CAG was 50-59 years old,and male patients accounted for the majority(61.47%).2.The patients of different age groups were more common in rural and Han populations and generally had no family history.3.There are significant differences in gender composition and body mass index among patients of different age groups.The middle-aged and young people are more common in male patients and have higher body mass index.The elderly patients are more common in female patients and the body mass index is lower.4.The general clinical manifestations of patients with CAG in different age groups were higher than those in the younger group,with more abdominal pain,nausea/vomiting,and diarrhea more common in the elderly group.There was no significant difference between the two groups.Overall,the incidence of common clinical symptoms of CAG was from high to low,respectively.early fullness122 cases(52.81%),analgesia 119 cases(51.52%),abdominal pain 119 cases(51.52%),hernia 117 cases(50.65%).5.There was no significant difference in laboratory examinations between patients of different age groups.The overall abnormal laboratory examinations of CAG were Hp infection and Hb decline.The incidence rates were 71.43% and 26.41%,respectively.6.The characteristics of gastroscopy in patients with different ages can be traced by gastroscopy,except that erosion was more common in the young group than in the young group.There were no significant differences in the other groups.The common CAG common gastroscopy associated with lesions was mucosal vascular exposure,mucosal granules or nodules,with an incidence of 44.16% and 38.11%.7.The pathological biopsy results of gastric mucosa in patients with different ages of CAG were significantly different.The young group had mild to moderate atrophy.The incidence of intestinal metaplasia was lower.The incidence was moderate and mild,and the incidence of intraepithelial neoplasia was significant.Lower,mainly in low grade;middle-aged group mainly in moderate,mild atrophy,low incidence of intestinal metaplasia,moderate to severe,low incidence of intraepithelial neoplasia,with low level In the old age group,moderate and severe atrophy dominated,and the incidence of intestinal metaplasia was low,with moderate and mild predominance.The incidence of intraepithelial neoplasia was low,with high grade as the main.Conclusion:CAG is a common precancerous disease of gastric cancer.It is more common in male patients.The incidence rate of rural and Han populations is higher.Its clinical manifestations are diverse and there is no obvious specificity.Routine examination and laboratory tests can not provide the final diagnosis basis.The diagnosis depends on pathological tissue.Examination,specific etiology and pathogenesis need to be further clarified.At present,treatment is mainly symptomatic.With the development of relevant basic medical research and the upgrading of diagnostic and treatment equipment,CAG’s diagnosis and treatment are rapidly developing in a non-invasive,accurate,and efficient manner.Chinese medicine has rich theoretical connotations for CAG’s cognition.Under the guidance of overall syndrome differentiation and treatment,it has achieved high clinical therapeutic effect,providing a reliable reference for clinical diagnosis and treatment of CAG.