Correlation Of Vitamin D Level With Carotid Intima-Media Thickness And Central Aortic Pressure In Patients With Essential Hypertension

Objective: To investigate the correlation between 1,25-dihydroxy vitamin D level and carotid intima-media thickness(IMT)and central aortic pressure(CAP)in Xinjiang Han and Uygur patients with essential hypertension.Methods: We selected 400 patients hospitalized in Department of Hypertension,the First Affiliated Hospital of Xinjiang Medical University and diagnosed with essential hypertension from 2012 to 2016.According to the serum 25(OH)D level,Han patients were divided into Han deficiency group(n=154)and Han sufficiency group(n=93),and Uygur patients were divided into Uygur deficiency group(n=92)and Uygur sufficiency group(n=61).Total cholesterol,triglyceride,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),IMT,and CAP indexes including central arterial systolic pressure(CSP),central arterial diastolic blood pressure(CDP),central arterial pulse pressure(CPP),augmented pressure(AP)and augmentation index(AIx)were measured in all patients.Results: IMT was significantly higher in Han deficiency group than in Han sufficiency group(P<0.05).The level of HDL-C was significantly lower and carotid IMT was significantly higher in Uygur deficiency group than in Uygur sufficiency group(P<0.05).CSP and CPP were significantly higher in Uygur deficiency group than in Uygur sufficiency group(P<0.05).Pearson correlation analysis showed that 25(OH)D was negatively associated with carotid IMT in Han patients(r=-0.534,P<0.001),and was negatively associated with IMT,CSP and CPP in Uygur patients(r=-0.432,r=-0.171,r=-0.290,P<0.05).Multivariate regression analysis showed that gender(t=-3.160),age(t=3.274)and 25(OH)D level(t=-9.633)were the influencing factors of IMT in Han patients(P<0.05).Age(t=2.519)and 25(OH)D(t=-5.990)level were the influencing factors of IMT in Uygur patients(P<0.05).Conclusion: Serum 25(OH)D level was an independent risk factor of increased carotid IMT in Han and Uygur patients.The deficiency in 25(OH)D was a risk factor of increased CSP and CPP in Uygur patients,which was not related to CAP in Han patients.