Correlation Study Of Serum Selenium Levels And Urinary Iodine Levels On Thyroid Cancer

Explore To grope for the filiation between iodine,selenium nutrition state with thyroid cancer.Method This study enrolled 153 cases of thyroid cancer,154 cases of benign thyroid nodule and 327 controls between March 2014 and December 2014.Patient demographic information was obtained.Serum TT3,TT4,TSH,TgAb,TPOAb,serum selenium concentration(Se),and urinary iodine concentration(UIC)were recorded for statistical analysis,study on the effect of sex,age,serum selenium level and urinary iodine levels on the prevalence of thyroid cancer by multivariate stepwise logistic regression analysis.Results Significant difference was observed in gender,age,and serum TT3,TT4,TSH,TgAb,TPOAb and Se levels as well as UIC in the thyroid cancer,benign thyroid nodule and normal thyroid shape groups(P<0.05).Serum TT3 and TT4 levels were significantly lower in the thyroid cancer group than that in the benign thyroid nodule and normal thyroid shape groups(P<0.001).In addition,the thyroid cancer group showed significant difference in serum TSH and Tg Ab levels from the group of benign thyroid nodule(P<0.05).Significantly a higher serum TPOAb level was noted in the groups of thyroid can cer and benign thyroid nodule than in the normal thyroid shape groups(P<0.05).Between different serum Se level subgroups,difference was noted in the serum TT3,TSH and TPOAb levels with significance(P<0.001)instead of TT4 and Tg Ab.Multivariate logistic regression analysis revealed that female,low Se level and high UIC were risk factors for thyroid cancer.Conclusions female,low selenium and high iodine might be associated with thyroid cancer.