The Effect Of Multi-Modal Analgesia On Postoperative Cortisol And Inflammatory Cytokines In Patients With Esophageal Cancer

Objective:To investigate the expression of Cor,inflammatory factor in esophageal cancer patients with multiple model analgesia.To provide the basis for the development of multimodal analgesia.Methods:Between October 2015 and October 2016,80 patients with esophageal cancer of People’s Hospital of Xinjiang Uygur Autonomous Region were randomly divided into group C（the control group）,group M₁、group M₂、group M₃,20cases in each group.Group M₁ was given intravenous parecoxib sodium and epidural fentanyl?before surgery;Group M₂ received intravenous parecoxib sodium before surgery and epidural fentanyl?after surgery;Group M₃ was given epidural fentanyl?before surgery and intravenous parecoxib sodium after surgery;Patients in Group C received normal saline treatment.VAS scores were recorded at 8h、12h、24h、48h,and the concentrations of Cor、IL-6、TNF-αwere also recorded at preoperative、end of operation、postoperative24h、48h.Results:8h,12h,24h and 48h after operation,The VAS score of the group M₁、group M₂、group M₃ was significantly lower than that of the group C,The VAS score of the group M₁ was significantly lower than that of the group M₂ and group M₃;24h and48h after operation,the levels of Cor、IL-6 and TNF-αin the group M₁、group M₂、group M₃ were significantly lower than those in the group C,The levels of Cor、IL-6 and TNF-αin the group M₁ were significantly lower than those in the group M₂ and group M₃（P<0.05）.Conclusion:A variety of ways combined with analgesia can reduce postoperative pain in patients with esophageal cancer,help reduce stress and inflammatory factors.