The Role Of CXCR1,CXCR2 And IL-8 In The Evaluation Of The Condition And Prognosis Of Elderly Patients With Community-Acquired Pneumonia

BackgroundCommunity Acquired Pneumonia(CAP)induces hypoperfusion and septic shock through multiple mechanisms,leading to organ dysfunction and death.Therefore,the detection and prognosis of elderly patients with CAP is the premise and basis for the treatment of elderly CAP.CXCR1,CXCR2 and IL-8 are involved in the regulation of cell growth and apoptosis,inflammatory response,oxidative stress[1].However,the role of CXCR1,CXCR2 and IL-8 in elderly patients with CAP remains to be further explored.ObjectiveTo investigate the role of CXCR1,CXCR2 and IL-8 in evaluating the condition and prognosis of elderly patients with community-acquired pneumonia(CAP).MethodsSelected blood samples of 78 elderly patients with CAP and 50 healthy volunteers from the Department of Respiratory Diseases of our hospital between June 2015 to June 2016 are studied.The levels of CXCR1,CXCR2,and IL-8 before and after treatment were measured using RT-PCR and immunohistochemistry based on pneumonia severity index(PSI)scores.ResultsThe levels of CXCR1,CXCR2 and IL-8 in elderly patients with CAP were significantly higher than those in healthy controls’(P<0.05).After adjusting for age and sex,PSI score was significantly associated with the above-measured indexs in CAP patients(P<0.05).After treated with antibiotics,mRNA expression of CXCR1,CXCR2 and IL-8 in elderly patients with CAP decreased significantly(P<0.05).ConclusionsCXCRl,CXCR2 and IL-8 have clinical value in evaluating the condition and prognosis of elderly patients with CAP.