Correlation Between Smoking And ABCA1、ABCG1 Levels In Patients With ICAS And The TCM Syndrome Analysis

Objective:1.The level of ABCA1 、 ABCG1 in plasma of patients with intracranial artery stenosis was detected by ELISA monitoring method,and the correlation between smoking and ICAS and ABCA1、ABCG1levels in plasma was investigated.2.By looking at,smelling,asking,cutting and obtaining the medical records of ICAS patients,the distribution of TCM syndromes in ICAS patients was discussed.Methods:1.Methods 185 patients with male cerebral infarction admitted to neurology department of Wuhan General Hospita of Guangzhou Military Region from January 2016 to 2017 were collected and confirmed by cranial CT and/or MRI.The 320 row CTA examination of head was completed within 1 weeks after admission.According to ICAS,all the patients were divided into the following three groups:89patients with multiple stenosis of intracranial artery,57 patients with single stenosis of intracranial artery and 39 patients with no stenosis of intracranial artery.Serum lipids and blood glucose levels.According to the smoking condition,the patients were divided into the following threegroups: smoking group(n=90),smoking cessation group(n=21)and non-smoking group(n=74).2.The medical records of 185 patients with intracranial artery stenosis were obtained,and the TCM syndromes were determined according to the tongue,pulse and other symptoms and signs,and the differences of syndromes among different stenosis patients were compared.Results:1.There was no significant difference in the general data between the three groups(P?0.05).There was no significant difference in the general data between the three groups(P ? 0.05).The levels of ABCA1 and ABCG1 in smoking group,smoking cessation group and non smoking group were significantly different in the 3 groups.The level of ABCA1 in smoking group was significantly lower than that in smoking cessation group and non-smoking group(P<0.05,P<0.05).There was no significant difference in ABCA1 level between smoking cessation group and non-smoking group(P>0.05).The level of ABCG1 in smoking group was significantly lower than that in smoking cessation group and non-smoking group(P<0.05,P<0.05).There was no significant difference in ABCG1 level between smoking cessation group and non-smoking group(P > 0.05).There were significant differences in ABCA1 + ABCG1 levels among three groups:multiple stenosis group,single stenosis group and no stenosis group.The level of ABCA1 in multiple intracranial artery stenosis group was significantly lower than that in single stenosis group and non-stenosis group(P<0.05,P<0.05).The ABCA1 level in single stenosis group was significantly lower than that in non-stenosis group(P<0.05).The level of ABCG1 in multiple intracranial artery stenosis group was significantly lower than that in single stenosis group andnon-stenosis group(P<0.05,P<0.05).The ABCG1 level in single stenosis group was significantly lower than that in non-stenosis group(P<0.05,P<0.05).2.In the group of multiple stenosis of intracranial artery,42 cases were single syndromes,including wind syndrome(20 cases),heat syndrome(2 cases),phlegm syndrome(9 cases),blood stasis syndrome(3 cases),deficiency of qi syndrome(4 cases),yin deficiency syndrome(4cases)and hyperactivity of yang syndrome(4 cases).There were 4cases of qi deficiency in wind syndrome,8 cases of phlegm syndrome and 8 cases of blood stasis syndrome,2 cases of qi deficiency syndrome of blood stasis syndrome.In the single stenosis group of intracranial artery,31 cases were single syndromes,including 13 cases of wind syndrome,3 cases of fire heat syndrome,7 cases of phlegm syndrome,1 case of blood stasis syndrome,4 cases of qi deficiency syndrome;Yin deficiency yang hyperactivity syndrome 3.There are 26 complex syndromes,including wind syndrome phlegm syndrome 20people;wind syndrome qi deficiency syndrome 1 person;phlegm syndrome blood There were 24 cases of single syndrome in the group of no stenosis of intracranial artery,including 10 cases of wind syndrome,2 cases of fire heat syndrome,5 cases of phlegm syndrome,3cases of blood stasis syndrome,2 cases of qi deficiency syndrome,3cases of blood stasis syndrome,2 cases of qi deficiency syndrome,3cases of blood stasis syndrome and 2 cases of qi deficiency syndrome.There are 15 syndromes,including wind syndrome phlegm syndrome 10 cases,wind syndrome qi deficiency syndrome 2 people,phlegm syndrome blood stasis syndrome 2 people,blood stasis syndrome Qi deficiency syndrome 1 person,intracranial artery multiple stenosis group,intracranial artery single stenosis group,There was nosignificant difference in the distribution of TCM syndromes among three groups of patients without intracranial artery stenosis.Conclusions:1.There was a significant correlation between smoking and plasma ABCA1-ABCG1 levels.Smoking could reduce the ABCA1-ABCG1 level in plasma,and smoking cessation could improve ABCA1-ABCG1 level.2.There was a significant correlation between the level of ABCA1 and ABCG1 in plasma,and the degree of intracranial artery stenosis and the number of branches increased with the decrease of ABCA1 / ABCG1 level.3.Smoking can affect the metabolism of blood lipids by decreasing ABCA1 / ABCG1 level,and then lead to the occurrence and development of intracranial multiple arterial stenosis.4.The most common TCM syndromes of intracranial artery stenosis are wind syndrome phlegm syndrome wind syndrome phlegm syndrome;there is no significant difference in the distribution of TCM syndromes between multiple intracranial artery stenosis single stenosis and no stenosis.