| Objects: To analyze the perioperative period risk factors of esophagogastric anastomotic leakage after esophagectomy,in order to explore methods to pervent and reduce the occurence of anastomotic leakage.Methods: Retrospective analysis of the clinical data of 416 patients who underwent esophagectomy from June 2014 to June 2016 in Department of thoracic surgery of the Nanjing Drum Tower Hospital.Through the literature and combined with clinical observation,the choice of esophagogastric anastomotic leakage may be related to the occurrence of factors.Univariate analysis was used to identify the risk factors of esophagogastric anastomotic leakage.Logistic regression analysis was used to identify the independent risk factors of esophagogastric anastomotic leakage.Results: From a total of 416 included patients,28(6.7%)developed anastomotic leakage,including 9 cases of cervical esophagogastric anastomotic leakage and 19 cases of thoracic esophagogastric anastomotic leakage.Univariate analysis showed that 9 factors were related to esophagogastric anastomotic leakage,they were smoking,tumor location,calcifications of arteries,surgery type,anastomotic site,operating time,one lung ventilation time,the CRP on second day and postoperative pulmonary complications(all P<0.05).Multivariate logistic analysis showed that calcifications of the celiac axis,anastomotic site and postoperative pulmonary complications are risk factors for esophagogastric anastomotic leakage after resection of esophageal carcinoma.Conclusion: 1.Calcifications of the celiac axis,anastomotic site and postoperative pulmonary complications are independent risk factors for esophagogastric anastomotic leakage after resection of esophageal carcinoma.2.Patients who underwent esophgectmy need strengthen perioperative respiratory managment to reduce the occurrence of postoperative pulmonary complications.3.Calcification of celiac axis is a new risk factor for esophageal anastomotic leakage. |
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