Prognostic Analysis Of Patients With Family History Of Coronary Heart Disease After PCI

Objective:To analyze the prognosis of percutaneous coronary intervention(PCI)in patients with family history of coronary heart disease and its influencing factors.Methods:A total of 13,800 patients with CHD who underwent PCI were enrolled from 2006-12 to 2016-6 in the TEDA International Cardiovascular Hospital.By telephone,outpatient and hospital review and other follow-up screening out of which with coronary heart disease family history,for the positive group.A total of 1028 patients with no family history of coronary heart disease who underwent coronary angiography with coronary artery disease were randomly divided into control group.The mean follow-up time was 59 ± 23.7(1 ~ 120)months.The follow-up endpoint was major cardiovascular adverse events(MACE),including re-myocardial infarction,revascularization,heart failure,cardiac death,and all-cause death.Survival curves were recorded by Kaplan-Meier method,and independent predictors of prognosis were analyzed by COX multivariate regression.Results: Family history positive group BMI,diabetes,hypertension and the incidence of negative group was no significant difference.The incidence rate and smoking rate of the positive group were significantly lower than those of the negative group,while the incidence of males and hyperlipidemia was significantly higher than that of the negative group.The proportion of blood glucose and blood lipid control in the family history group was higher than that in the negative group.There was no significant difference in blood pressure control between the two groups.The proportion of ACEI / ARB,statins and bRB drugs in family history group was higher than that in negative group.Calcium channel blockers(CCB)drugs,the two groups were no significant differences in the use and no statistically significant.The mean follow-up was 59 ± 23.7(1 ~ 120)months.The total MACE event occurred in the family history group was higher than the negative group.Re-myocardial infarction,revascularization and heart failure were statistically significant coronary heart disease were also higher than the negative group.All-cause mortality and cardiac mortality positive group were lower than negative group.Kaplan-Meier method was used to analyze the incidence of MACE events after PCI: During the period of follow-up,the incidence of total MACE,re-myocardial infarction and revascularization was higher in the positive group than in the negative group,and the incidence of all-cause and cardiac death was lower in the negative group than in the negative group.The family history of coronary heart disease is an independent risk factor for total MACE,re-myocardial infarction,and once again revascularization events,and is a protective factor for all-cause and cardiac death events.Conclusions: The positive rate of family history of coronary heart disease in patients with PCI was 9.4%.The average age of onset of coronary heart disease is small,the smoking rate is low,while the number of men and hyperlipidemia is higher.Postoperative follow-up of PCI: The blood pressure,blood lipid and blood glucose were higher in the family history group,and the proportion of ACEI / ARB,statins and bRB was also higher than that of the negative group.In addition,compared with patients without family history of coronary heart disease,positive group of patients after PCI,although the incidence of MACE events,but the low mortality rate.Factors affecting the prognosis of patients after PCI showed: The family history of coronary heart disease is an independent risk factor for total MACE,re-myocardial infarction,and once again revascularization events,and is a protective factor for all-cause and cardiac death events.