| Objective: Through undergoing dynamic contrast-enhanced MRI(dynamic contrast-enhanced MRI,DCE-MRI)before operation to provide quantitative basis for the differential diagnosis of high-grade gliomas and low-grade gliomas.And determine whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably.Material and Methods: Twenty –three cases of High Grade gliomas and twelve cases of Low Grade gliomas were enrolled.All of the patients underwent DCE-MRI before operation.The pharmacokinetic model of was used to calculate the datas,the tissue enhancement-time curve and pharmacokinetic parameters(volume transfer constant,Ktrans,extracellular extravascular volume fraction,Ve,and blood plasma fraction,Vp;Microvas-cular permeability reflux constant,Kep)of the lesion,solid components were obtained.Ktrans value,Ve value and Vp value were compared to judge whether there were significant differences between the two kinds of tumors.The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas,the tissue enhancement–time curve and pharmacokinetic parameters(Ktrans,Ve and Vp)of the lesion,solid components were obtained.Ktrans value,Ve value and Vp value were compared to judge whether there were significant differences between the low-grade glioma and the high-grade glioma of the two groups(survey one and survey two),and whether the pharmacokinetic model of Extended Tofts Linear could operate reproduceably.Results: The values of Ktrans、Ve 、Vp and Kep in the parenchyma of HGG and in the LGG were statistically significant(P<0.05).There was no statistical significant between the Ktrans values 、 Ve and Vp values in the peritumoral edema of HGG and LGG(P>0.05),.The Intraclass Correlation Coefficient(ICC)values of Ktrans 、 Ve and Vp were 0.93,0.809,0.592 separately>0.4.Conclusion: Ktrans 、Ve and Vp values in the parenchyma and peritumoral edema may be useful in the differentiating LGG between HGG,The reproducibility of the DCE-MRI Extended Tofts Linear is good. |
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