Correlation Analysis Of Glucose And Lipid Metabolism And Hemorheology In Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective To investigate the effects of glycolipid metabolism on hemorheology in patients with obstructive sleep apnea hypopnea syndrome.Method According to the diagnostic criteria,70 patients with OSHAS and 20 healthy controls were enrolled.The OSAHS patients were divided into mild group(n= 17),moderate group(n = 25)and severe group(n = 28).Participants were measured height,weight.And calculate the body mass index(BMI).All participants were subjected to polysomnography monitoring,recording apnea hypopnea index(AHI),minimum oxygen saturation(Minxy saturation,MinSPO2),determination of fasting blood glucose,blood lipids,adiponectin,hemorheology indicators.Compare the difference between the indexes of fasting blood glucose,blood lipid,adiponectin and hemorheology in each group of OSAHS group and control group.Analyze correlation between blood rheology and glucose and lipid metabolism,AHI,minimum oxygen saturation,and body mass index were analyzed in OSAHS patients.Result 1.OSHAS patients compared with the control group:blood glucose,cholesterol,triglyceride,whole blood viscosity,plasma viscosity,high blood viscosity,low blood viscosity,erythrocyte aggregation index were higher than the control group(P<0.05),high density lipoprotein,adiponectin,erythrocyte deformation index lower than the control group(P<0.05).2.each group in OSHAS patients compared with the control group: Adiponectin decreased gradually(P<0.05),and there was significant difference between the two groups(P<0.05).Blood glucose,cholesterol,triglyceride,whole blood viscosity,plasma viscosity,high blood viscosity,low blood viscosity were significantly increased in the each group in OSHAS patients(P<0.05),there was no difference between control group and mild group(P>0.05).Erythrocyte deformation index were decreased gradually in the each group in OSHAS patients(P<0.05),there were no difference between control group and mild group(P>0.05).The hematocrit of severe group was significantly higher than that of moderate group,mild group and control group(P<0.05).There was no significant difference between the severe group and the moderate group(P>0.05)but there were significant difference between the severe group、moderate group and the moderate group control group(P<0.05).The high density lipoprotein in severe and moderate group was lower than that in control group(P<0.05),and the severity group was lower than that in mild group(P<0.05).3.Analysis the inear correlation,hemorheological indexes were significantly correlated with glucose and lipid metabolism,AHI,minimum oxygen saturation and body mass index.,(P<0.05).In the further multivariate linear stepwise regression,the indexes of blood rheology were used as the strain,and the regression equation was established with the indexes of glucose and lipid metabolism,AHI,minimum oxygen saturation and body mass index as independent variables.The characteristics of hemorheology can be deduced from the independent variables.Conclusion There were glycolipid metabolic disorders and abnormal hemorheology in OSAHS patients:blood glucose,triglyceride,cholesterol,whole blood viscosity,plasma viscosity,high blood viscosity,low blood viscosity,red blood cell aggregation index increased,and the greater the severity of the disease,the greater the increase.Adiponectin,high density lipoprotein,erythrocyte deformation index were reduced,the greater the severity of the greater reduction.The indicators of glucose and lipid metabolism were significantly correlated with the indexes ofhemorheology,and the disorder of glucose and lipid metabolism was one of the reasons for the change of hemorheology.