The Clinical Significance Of Impulse Oscillometry System In The Assessment Of The Severity Of Chronic Obstructive Pulmonary Disease

Objective:By measure Impulse oscillometry system(IOS)and routine pulmonary function FEV1%pre and FEV1/FVC with stable chronic obstructive pulmonary disease(COPD),discuss Impulse oscillometry system for chronic obstructive pulmonary disease severity evaluation of clinical significance.Methods:Collected 214 cases in Shanxi dayi hospital diagnosed with stable COPD in July 2014 to June 2015,according to the GOLD(2011 edition)joint assessment method it can be divided into four groups A,B,C and D.Choose the health examination persons 41 cases for the same period as the healthy control group.IOS(Z5、R5、R20、R5﹣R20、X5、Fres)measurements and routine pulmonary function(FEV1%pre、FEV1/FVC)were performed for all the healthy subjects and patients.Results:1.In COPD,there were 164 males and 50 females,the mean age was 63.6±9.5 yrs.Among them,48 cases in group A,68 cases in group B,55 cases in group C and 43 cases in group D.In healthy control group,there were 26 males and 15 females,the mean age was 54.6±10.4 yrs.There was no significant difference in gender and mean age between COPD and healthy control group.2.In COPD group,Z5、R5、R20 、 R5﹣R20 and X5 of IOS were(0.70±0.30)、(0.62±0.25)、(0.36±0.12)、(0.26±0.18)and(-0.31±0.19)kPa/L/s respectively,Fres was(28.71±9.07)Hz,FEV1%pre and FEV1/FVC were(50.83±21.91)%and(51.57±11.29)%。Among these datas,Z5、R5、R20 、 R5﹣R20 and Fres were significantly higher than the control group(P<0.05),X5、FEV1%pre and FEV1/FVC were significant reduced(P <0.05).3.COPD patients with A,B,C and D four groups Z5,R5,R5﹣R20 and Fres increased,X5 decreased.Significant differences were detected among A,B and C groups(P <0.05).4.In COPD patients,Z5,R5,R5﹣R20 and Fres were significantly negatively correlated with FEV1%pre,which Fres and FEV1%pre correlation is the biggest(r=﹣0.599);X5 was significantly positively correlated with FEV1%pre.Among A,B,C and D four groups,IOS in each parameter and FEV1%pre correlation gradually decreased.Significant differences were detected among A,B and C groups(P <0.05).Conclusions:IOS can better reflect the changes of airway resistance in different groups of patients with COPD,and can better assess the severity of disease in patients with COPD,especially in elderly patients.