Correlation Between Hypoalbuminemia And The Severity Of Coronary Artery Lesions And Prognosis In Patients With Acute ST-segment Elevation Myocardial Infarction

Objective: To investigate the effect of hypoalbuminemia on severity of coronary artery lesions and the prognosis in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods: A retrospective study was conducted in all hospitalized patients who diagnosed as STEMI in 2014.According to the inclusion and exclusion criteria,all patients were divided into low serum albumin group(n=64)and normal serum albumin group(n=203).The coronary angiography results were collected,and the mortality rate and incidence of major adverse cardiovascular events(MACE)followed up for 1 year after myocardial infarction were also analyzed.Results: Compared with normal albumin group,patients in low serum albumin group were older,with lower BMI and blood pressure on admission(P<0.05).The latter group had higher KILLIP heart function classification,while exhibited higher incidence of triple vessel lesions(P=0.010).In addition,patients with hypoalbuminemia had a greater all-cause mortality in 1 year after myocardial infarction,along with a much higher rate of MACE in 7 days(P=0.004;P=0.021),however,the occurrence of bleeding events was comparable between the two groups(P=0.552).Multiple Cox proportional hazard analysis showed that hyponatremia remained as an independent predictor for all-cause death of STEMI after multivariable adjustment(HR=2.610,95%CI=1.165 to 5.848,P<0.05).Conclusion: Serum albumin level is of great value for assessing the severity of coronary artery lesions,and hypoalbuminemia is an independent risk factor for prognostic prediction of STEMI.