The Correlation Of Monocyte Chemotactic Protein-1 And Premature Rupture Of Membranes

Objective: To investigate the correlation of premature rupture of membranes between monocyte chemotactic protein-1(MCP-1)in cervical secretions and serum procalcitonin in pregnancy women.To analysis of the predictive value of monocyte chemotactic protein-1 and serum procalcitonin in the occurrence of premature rupture of membranes.Methods: From January 2015 to January 2016,120 cases of pregnant women(60 cases of preterm,group A;60 cases of full-term,group B)who had regular prenatal test and delivery at the Municiple Hospital of Qingdao were involved in this study.According to the gestational premature rupture of gestational age: 28 ~ 36 +6 weeks and pregnant ≥ 37 weeks,group A1,30 cases of preterm premature rupture of membranes.group B1,30 cases of term premature rupture of membranes.The normal control groups were divided into the control group,group A0,30 cases of preterm premature healthy;and group B0,30 cases of full-term healthy.Enzyme-linked immunosorbent assay(ELISA)was used to measure the levels of MCP-1 in cervical secretions and procalcitonin in the blood.The data of each group were statistically analyzed by t test,and P≤0.05 was statistically significant.Results: There was no significant difference between groups in age and gestational age,and there was no significant difference in the incidence of chorioamnionitis between preterm premature rupture of membranes and term premature rupture of membranes(20% and 13.3%,P>0.05).Comparison of MCP-1 level in cervical secretions: A1>A0(70.86±12.76pg/ml>16.64±2.97pg/ml,P<0.01),the differences between the two groups were statistically significant;B1>B0(30.26±5.22pg/ml>13.19±2.35pg/ml,P<0.05),the differences between the two groups were statistically significant;A1>B1(70.86±12.76pg/ml>30.26±5.22pg/ml),(P<0.01),the differences between the two groups were statistically significant.Comparison of serum procalcitonin level: A1>A0(0.95±0.32ng/ml>0.35±0.16ng/ml,P<0.05),the differences between the two groups were statistically significant;B1>B0(0.25±0.06ng/ml>0.05±0.02ng/ml,P<0.05),the differences between the two groups were statistically significant;A1>B1(0.95±0.32ng/ml>0.25±0.06ng/ml,P<0.05),the differences between the two groups were statistically significant.Conclusion 1.The level of MCP-1 in cervical secretions from premature rupture of membranes was significantly higher than that in normal control group,suggesting that the elevation of MCP-1 in cervical secretions was closely related to premature rupture of membranes.The level of MCP-1 in cervical secretions from preterm premature rupture of membranes were significantly higher than that in other groups,suggesting that elevation elevation of MCP-1 in cervical secretions may increase relationship with preterm premature rupture of membranes more closely.2.The level of MCP-1 protein in cervical secretions can be used as one of the important predictors of occurring preterm premature rupture of membranes.3.The significantly elevation of serum procalcitonin in preterm premature rupture of membranes suggested that procalcitonin levels in predicting preterm premature rupture of membranes is more sensitive.4.The combination of serum procalcitonin and the MCP-1 in cervical secretions may be useful in the prediction of preterm premature rupture of membranes.