Expression Of DEPDC1 In Epithelial Ovarian Tumors And Its Clinical Significance

Background: Epithelial ovarian cancer(EOC)is the leading cause of death from gynecologic malignancies.Ovarian Cancer(OC)is one of the three gynaecology common malignant tumor and it’s the first cause of death.Currently,tumor markers CA125 and HE4 have used in tumor screening,early diagnosis,rognostic analyses.But there are still lots of people diagnosed as advanced ovarian cancer.Bevacizumab has become ovarian cancer targeted therapy drugs.The therapeutic effects are unsatisfactory.DEP domain containing 1(DEPDC1)is a recently identified novel tumor-related gene that is upregulated in several types of cancer and contributes to tumorigenesis.DEPDC1 is a novel cell cycle related gene that regulates mitotic progression.DEPDC1 may take part in the development of ovarian cancer.There is still not related articles about DEPDC1 in ovarin cancer.Methods:We retrieved 47 paraffin-embedded specimens of surgically ovarian cancer,12 paraffin-embedded specimens of surgically ovarian benign tumor,15 paraffin-embedded specimens of surgically ovarian border ovrian and 18 paraffin-embedded specimens of surgically normal ovarian tissues resected between January 2013 and April 2016 at the Pathology Department of Yuhuangding Hospital Affiliated to Qingdao University and detected the expression of DEPDC1 by immunohistochemical methods,and Western Blot was used on protein quantitative validation.Results:The positivity rate of DEPDC-1 was 98.39 in EOC(it contains the border ovarian tumors)but only 10.0% in innocent and normal tumors(P<0.05).The overexpression level of DEPDC-1 was mainly associated with wether it is malignant tumor or not.However,FIGO stage and pathological type of tumor were not the influential factor of the expression level of DEPDC-1.There was a close correlation between the increase of CA125 and the up-regulation of DEPDC1.Conclusion:The expression level of DEPDC1 in EOC was significantly higher than that in innocent and normal tumors.DEPDC1 may be used in ovarin cancer on tumor screening,early diagnosis,rognostic analyses.It may become a therapeutic target in the future.