Tumors of the diffuse neuroendocrine cell system(DNES)may arise in any component of the gynecologic tract,including the vulva,vagina,cervix,endometrium,and ovary.Overall such tumors in the gynecologic tract are rare,constituting only 2% of gynecologic cancers comprising a spectrum of tumors of variable biologic potential[1].Most ovarian neuroendocrine tumor associated with ovarian surface epithelial tumors [2].Due to the rarity of such tumors,pathologists experience may be limited and these may present diagnostic challenges.Currently the nomenclature employed is still that of the pulmonary classification systems,carcinoid,atypical carcinoid,small and large cell neuroendocrine carcinoma.In this article we review the research progress of the neuroendocrine carcinoma of the ovary. |