Clinical Research Of Compound Glycyrrhizin Combined With Mizolastine In The Treatment Of PLE

Objective:To evaluate the clinical efficacy of Compound Glycyrrhizin combined with mizolastine in the treatment of Polymorphous light eruption.Methods:The 120 patients were randomly divided into three groups,who were consistent with inclusion criteria and exclusion criteria.The group of A was mizolastine,34 cases,the group of B,which was a group of hydroxychloroquine combined withmizolastine sulfate,38 cases,the group of C,which was a group of Compound Glycyrrhizin combined with mizolastaine,36 cases.Three groups of patients were treated with Butyl Flufenamate Ointment,who use it 2times in one day.The use of oral medication:Mizolastine Sustained-release Tablets,10 mg each time,1 times a day,Hydroxychloroquine Sulfate,0.2g each time,2 times one day,Compound one day,Compound Glycyrrhizin Tablets,50 mg each time,3 times one day.Three groups of patients before treatment,after treatment for 4 weeks,after treatment for 8 weeks to do minimal erythema dose(MED)and records,and each group of patients were evaluated effect,after 2 weeks,4 weeks,6 weeks,8 weeks,and recorded adverse reactions.Results:1.Cases were completed:108 cases were completed,and 12 cases were terminated.The three groups was A,B,C,whose completion rate was:85.00%,95.00%,90.00%,respectively.2.After 2 weeks of treatment,the total effective rates of the patients in the three groups were:41.2%,60.5%,61.11%,respectively.There was no statistical significance(P>0.05).3.After 4 weeks of treatment,the total effective rate of three groups:A,B,C was:64.7%,84.2%,77.8%,respectively,had no statistical significance(P>0.05),and markedly effective rate was:5.9%,34.2%,27.8%,between group A and group B,between group A and group C has statistical significance(P<0.05),between group B and C was no statistically significant(P>0.05).4.After 4 weeks of treatment,the MED values of the three groups were not statistically significant(P>0.05).5.After 6 weeks of treatment,three group of A,B,C,the total efficiency of them respectively was:73.5%,89.5%,88.8%,had no statistical significance(P>0.05).The cure rate of A,B,C was 14.7%,23.7%,36.1%,between group A and C group,there was statistical significance(P<0.05),other two groups were not statistically(P>0.05).The markedly effective rate respectively was:23.5%,63.1%,66.7%,group A compared with group B and group C has statistical significance(P<0.05),group B and group C was no statistical significance(P>0.05).6.After 8 weeks of treatment,three group of A,B,C,the total efficiency of three groups respectively was:85.2%,94.6%,91.6%,had no statistical significance(P>0.05),the cure rate was 23.5%,44.7%,44.4%,markedly effective rate respectively was 41.2%,81.6%,83.3%,between group A and group B,between group A and group C the markedly effective,cure rate were statistical significance(P<0.05),group B and group C has no significant difference.(P>0.05).7.After 8 weeks of treatment,the UVA-MED value of the three groups was not statistically significant compared with the former,the UVB-MED value of group A,B compared with the former has not statistically significant,the group C compared with the fourth weeks,there was statistical significance(P<0.05).Conclusion:1.compound glycyrrhizin,hydroxychloroquine sulfate respectively combined with mizolastinein、Butyl Flufenamate in the treatment of polymorphous light eruption are effectiv-e.2.Mizolastine respectively combined with Compound Glycyrrhizin,hydroxychloroquine sulfate in treatment of PLE,whose curative effect is better than mizolastine treatment alone.3.The effective of hydroxychloroquine sulfate combined with mizolastine,droperidol Ointment and compound glycyrrhizin in combination with mizolastine and Butyl Flufenamate ointment in treatment of polymorphous light eruption is quite satisfactory.4.The treatment of Compound Glycyrrhizin combined with mizolastine value impact on the part of patients with UVB-MED,but had no effect on UVA-MED.