Neuroplasticity Of Motor Aphasia Patients With Stroke:A Resting State BOLD-fMRI Study

Section ⅠApplication of ReHo in motor aphasia patients with stroke:A BOLD-fMRI studyObjective Adopting Regional homogeneity(ReHo)in blood oxygenation level dependent functional MRI(BOLD-fMRI)to investigate differences of regional brain activity in resting stateoccurrence and the rehabilitation of patients with motor aphasia patients with stroke.Methods Siemens verio 3.0T MR Scanner was used to obtain 12 patients with motor phasia and 10 no aphasia patients of fMRI data,Two fMRI examination was performed in patients with motor phasia,within 7 days and 1 months after the onset of the disease.The fMRI data were processed with the software of SPM8 and DPARSF,the data processing includes the time correction,dynamic correction,spatial standardization,elimination of the linear trend,elimination of the low frequency drift and the high frequency noise.group analysis was performed with two sample t-test and paired t-test by REST software,and obtain increased and decreased ReHo map.Generate activation maps to view related brain activation maps use Slice Views.Results In this experiment,after the preprocessed and head too big during the scanning process,10 patients with motor aphasia、6 patients with motor aphasia after 1 month recovery and 10 no aphasia patients were recruited in each group.As compared with the control group,aphasia patients(within 7 days of onset)the regions showing increased ReHo in aphasia patients were distributed in left cerebellum,left occipital lobe and right middle temporal gyrus;while the regions showing decreased ReHo covered the left medial prefrontal gyrus,left superior frontal gyrus,left middle frontal gyrus,left angular gyrus,left parietal lobe,right occipital lobe,right angular gyrus,right supramarginal gyrus,bilateral superior parietal lobule and inferior parietal lobule.As compared with those in control group,aphasia patients(after 1 months)the regions showing increased ReHo in aphasia patients were distributed in the left inferior frontal operculum,left precuneus,left precentral gyrus,left superior parietal lobule,left middle frontal gyrus,right parahippocampal gyrus and right angular gyrus;while the regions showing decreased ReHo covered the left cerebellum,left superior frontal gyrus,left anterior limb and right middle frontal gyrus,right parietal lobe and bilateral inferior parietal lobule.As compared with the aphasia patients(within 7 days of onset),after 1 months increased ReHo in aphasia patients were distributed left anterior central gyrus and superior parietal gyrus.Conclusion 1、The left medial prefrontal gyrus,left superior frontal gyrus,left middle frontal gyrus,left angular gyrus,left parietal lobe,right angular gyrus,right supramarginal gyrus,right occipital lobe,parietal lobe and inferior parietal lobule of ReHo signal decreased in 7 days after the onset of aphasia,suggest that functional changes in the brain areas may be related to the activity of neurons in the local lesion.2、The left inferior frontal operculum,left precuneus,left precentral gyrus,left superior parietal lobule,left middle frontal gyrus,right parahippocampal gyrus and right angular gyrus of ReHo signal increased in the aphasia patients after 1 months,Prompt may play a compensatory role for recovery of language.3、In the early stage of motor aphasia patients after stroke brain regions of the right hemisphere activation increased,functional reorganization of left cerebral hemisphere without injury was mainly in the chronic phase,is a result of interaction between the hemispheres,and the right hemisphere was also involved in this process.Section ⅡFunctional connectivity study in resting-state in motor aphasia patients after strokeObjective Analysis by using the method of seed point function connection in motor aphasia patients with stroke within 7 days and after 1 month,investigate the plasticity mechanism of motor aphasia patients.Methods The fMRI data were processed witht the same as the Section I.The nuisance covariates including global trend signal,white matter(WM)signal and cerebrospinal fluid(CSF)signal.The left middle frontal gyrus(LFMG)is selected as a ROI,the coordinates of ROI seed point is(-40,10,55),we analyzed the time course correlation between LFMG-ROI with the other areas of the whole brain and obtain the Pearson correlation diagram.analysis was performed with two t-test and paired sample t-test.Statistical parameter mapping was overlapped onto MNI standard triaxiality template of Slice Viewer,and generating function connection diagram.Results In the resting state,aphasia patients(within 7 days of onset)LMFG-ROI positively correlated with right frontal gyrus,right inferior frontal gyrus,negative correlation were left cerebellum,left posterior cingulate gyrus,left lateral capsule,left insular lobe,left occipital lobe,left superior parietal lobule.aphasia patients(after 1 months)LMFG-ROI positively correlated with left middle frontal gyrus,inferior frontal gyrus,left superior frontal gyrus,left insula,left posterior cortex,negative correlation were left cerebellum,right temporal lobe,right insular lobe,right posterior central gyrus,bilateral cingulate gyrus,bilateral occipital lobe.As compared with the control group,aphasia patients(within 7 days of onset)the regions showing increased FC in aphasia patients were distributed in right insula,right frontal parietal operculum,right inferior frontal gyrus(triangular,orbital)and right temporal gyrus and superior temporal gyrus,right supramarginal gyrus,right angular gyrus;while the regions showing decreased FC covered left anterior cingulate gyrus,left praecuneus.As compared with the control group,aphasia patients(after 1 months)the regions showing increased FC in aphasia patients were distributed in the left head of caudate,left middle frontal gyrus and inferior frontal gyrus,left pallidum,left precentral gyrus and postcentral gyrus,left insula;while the regions showing decreased FC covered the left posterior cingulate gyrus,left cerebellum,right hippocampus,right lingual gyrus,right occipital lobe,right praecuneus.As compared with the aphasia patients(within 7 days of onset),after 1 months increased FC in aphasia patients were distributed Left middle frontal gyrus,left inferior parietal lobe,left anterior central gyrus and posterior central gyrus decreased FC Including the right superior temporal gyrus,right middle temporal gyrus,right insula and right supramarginal gyrus.Conclusion 1、The right side of neural network correlated with LFMG-ROI was significantly higher in early stage of motor aphasia patients in resting-state,which might be the Compensatory after brain injury.2、Correlated with LFMG-ROI was mainly in the left hemisphere of the brain in motor aphasia patients after 1 month,functional connectivity enhances brain areas from the right hemisphere to the left hemisphere,this may be the main mechanism for the recovery of aphsaia patients in the chronic phase.3、Whether in the acute or chronic phase,we found activation decreased of left cingulate gyrus,considering this is the important area of the mechanism of motor aphasia.