Analysis Of Etiology And Related Factors Of 430 Cases Of Neonatal Hyperbilirubinemia In Lanzhou Area

Objective: To explore the etiology and related factors of neonatal hyperbilirubinemia in Lanzhou area,and to provide clinical basis for the prevention and reduction of neonatal hyperbilirubinemia.Methods: The clinical data of 430 children with hyperbilirubinemia were enrolled in the Department of Neonatology,the First Hospital of Lanzhou University from January 2011 to December 2015.According to the birth gestational age divided into full-term children and preterm children group,gestational aged≥37 weeks were term infants,gestational age<37 weeks for preterm children;According to infection factors caused by jaundice infection group,non-infectious factors Caused by jaundice were non-infected group.Results: In infection factors,Pneumonia was considered as the first cause accounting for 33.80%,followed by sepsis accounting for 23.47%;In the non-infection factors,hemolysis was considered as the first cause accounting for 24.65%,followed by perinatal factors accounting for16.05%.Compared with the preterm i nfants,the term infants had treatment and jaundice peak at later time and shorter time of hospital(P<0.05).Compared with the non-infection infants,the infection infants ha d smaller gestational age,later time of jaundice appearance and peak,lower decline ra te of jaundice and shorter time of hospital(P<0.05).According to whether the merger with bilirubin encephalopathy is divided into bilirubin encephalopathy group(referred to as encephalopathy group)and non-bilirubin encephalopathy group(referred to as non-encephalopathy group);Multivariate logistic regression analysis was performed on the factors affecting bilirubin encephalopathy.Univariate analysis revealed that exclusive breastfeeding rate,peak TSB,peak indirect bilirubin and B/A were significantly different between in bilirubin encephalopathy group than in non-bilirubin encephalopathy group(P<0.05,OR= 0.889),multivariate logistic regression analysis showed that the peak age of jaundice was the protective factor of bilirubin encephalopathy,which premature delivery,jaundice was long,the B/A was large,peak TSB was high and peak indirect bilirubin was high is a risk factor forbilirubin encephalopathy(P < 0.05,OR espectively 1.361,1.127,1.600,1.036,1.032).Conclusions: The main disease of neonatal hyperbilirubin is the infection and haemolysis,followed by the factors of perinatal factors.To prevent infection of hemolytic disease of prenatal screening and perinatal health care,improve the mechanism of the follow-up after discharge,to have children with risk factors,timely follow-up,early intervention,reduce high blood bilirubin and bilirubin encephalopathy.