Rapid Screening Of Multidrug-Resistant Organism Among Patients Admitted To Hospitals Of Xicheng District

Aims: A survey was conduted to determine the prevalence and risk factors of Multidrug-Resistant Organism among patients admitted to hospitals of xicheng district.Methods: A prospective cohort study was conduted from June,1st,2014 to September 30 th,2015 in ten hospitals of xicheng district.Patients were divided into research group(top three hospitals)and control group(directly from community),nasal swabs and(or)anal swabs were collected,then we used Chromogenic culture medium technology to indentify Methicillin-resistant Stphylococcus aureus,Extended spectrum beta lactamase producing Enterobacteriaceae and Vancomycin-resistant Enterococcus,hoping to know the positive rate and distribution of multi-resistant organism strains oftwogroups.To find out the risk factors of Multidrug-Resistant Organism carriage,Demographic characteristics,pastmedical history,treatment condition prior to admission,vitalsigns,infection related situation on the day of admission were also collected.Results: 644 patients addmitted to ten hospitals underwent rapid screening of multdrugi-resistant bacteria,304 cases in control group while 340 cases in research group,among these patients,333 were male aged from 56 to 82 years old.Of all the 644 patients,395 cases(61.3%)were multidrug-resistant organism positive,the research group,220 cases(72.4%),significantly higher than the control group,175 cases(51.5%).The positive rate of Nasal swabs are much higher in research group than the control group(11.8% vs 3.2%,P< 0.05),especially for MRSA.And the positive rate of anal swabt,both groups were higher than the nasal swabs.Conditions that rapid screening showed two or more probability of multidrug-resistant organism,research group is significantly higher than the control group(18.9% vs 12.8%,P = 0.046),especially for Extended spectrum beta lactamase producing Enterobacteriaceae.According to the results of screening,patients were divided into positive group and negative group.In positive group,more patient had been suffered from cerebrovascular disease(28.1% vs 17.3%,P = 0.02),had surgery within 4 weeks(21.0% vs 12.9%,P = 0.008),history of antibiotic exposure 4 weeks prior to admission(38.0% vs 24.9%,P = 0.001),the history of cerebrovascular disease,surgery within 4 weeks were both risk factors for colonization/infection of multidrug-resistant organism.Conclusions: The positive rate of multidrug-resistant organism on patients from Xicheng district hospitals.Patients from top three hospitals are more likely to colonize with multidrug-resistant organism than those from community.The positive rate of Nasal swabs are much higher in research group than the control group,especially for MRSA.As for anal swabt,research group is significantly higher than the control group,especially for Extended spectrum beta lactamase producing Enterobacteriaceae.the history of cerebrovascular disease,surgery within 4 weeks were both risk factors for colonization/infection of multidrug-resistant organism.