Analysis Of The Pathological Characteristics Of Placenta Of Fetal With Congenital Heart Disease

Objective:To investigate the pathological characteristics of placenta pathological changes of fetal with congenital heart disease.Metheds:From August 2010 to April 2014 in the Department of Ultrasound in Beijing Anzhen Hospital and Fetal Heart Disease Maternal Fetal Medicine Research Important Laboratories,20 cases induced by congenital heart disease(heart disease group,all of the fetuses due to cardiac malformations induced labor),and 34 cases which prenatal ultrasound and postpartum examination were normal,but induced by premature rupture of fetal membranes,hypamnion,gestational diabetes mellitus,preeclampsia,intrauterine asphyxia,threatened abortion,pregnant women of arrhythmia(control group).An analysis of fetal prenatal ultrasound and postpartum placental pathology were performed between the 2 groups.Results: In the placenta of congenital heart disease group,17 cases were in the second trimester of pregnancy,3 cases were in the late stage of pregnancy.In the placenta of control group,34 cases were all in the later stage of pregnancy.Postpartum placental pathological examination showed:(1)There were 18 cases with placental lesions in the heart disease group(18/20),with severe chorionic villositis(77.8%,14/18),focal calcification(44.4%,8/18)and thrombosis(16.7%,3/18)as the main,one case of placenta infarction,two cases of non significant changes were found in placenta or umbilical cord.(2)Ten cases of placenta lesions of fetal with lethal congenital heart disease was more serious than the other 10 cases of placenta lesions of fetal with non lethal congenital heart malformation in heart disease group.(3)All the 34 cases with placental lesions were found in the control group(34/34),with mild chorionic villositis(61.8%,21/34),focal calcification(79.4%,27/34)and cellulose like substance(97.1%,33/34)as the main,with severe chorionic villositis(26.5%,9/34)as a part.(4)The comparable results of pathologic examination in heartdisease group and control group showed that fetal placenta lesions in the heart disease group were more serious than that in the control group.Both the pathological characteristics of placenta lesions in the two groups and the ultrasound performances were different.Conculusion: Severe placental chorionic inflammation,focal calcification and thrombosis of placenta in congenital heart disease group affect the maternal fetal blood circulation and exchange of nutrients,which may associated with the incidence of congenital heart disease.