Quality Standards Study Of Traditional Chinese Medicine Keel,Oysters Superfine Powder

Objective:Mineral medicine,animal shell drugs,its main ingredients for inorganic(calcium and trace elements),their main is the dissolution of the principal component molecules from crystal to the process of solvent.If the medicine pieces,and increase the drug than surface area is helpful for the active components of crude dissolution.Superfine powder is superfine grinding of the final product,superfine grinding raw materials can be crushed to micro,sub-micron level,it has generally don’t have some of the powder special physical and chemical properties,such as good dispersion,solubility,etc.Superfine grinding technology import Chinese medicine field,produce the micron Chinese traditional medicine,but in Chinese medicine pharmaceutical application in industry is still in the stage of exploration,the powder quality standardization system is yet to be perfect,should strengthen the powder preparation technology,quality standards and main pharmacodynamics system research.This papers to the keel,oysters as the research object,and explore the keel,oysters superfine powder production process,main component content limit,main component dissolution and the relationship of particle size,for traditional Chinese medicine industry quality standard of superfine powder formulating and provide perfect test data.Methods:(1)the keel,oysters superfine powder preparation process:to the D50 and solubility of examination indexes,the superfine grinding time,temperature,into the ground before drying time,medium filling rate for research.(2)keel,oysters superfine powder and physical properties characterization of research:from the appearance of characters,solubility,powder loose density,specific surface area of keel,oysters powder characterized.(3)keel,oysters and superfine powder of the X ray diffraction a Fourier fingerprint standard fingerprint and characteristics of the peak value of mark built up,keel,oysters superfine yinpian mutual fingerprint peak(4)keel,oysters calcium and trace elements in research:the classic method of EDTA titrimetric method keel,the calcium content of oysters were;By using atomic absorption spectrometry Zn,Cu that its contain,Mn,Fe,Cd five kinds of trace elements in.(5)traditional Chinese medicine keel,oysters to fiy the problem study:to the traditional Chinese medicine keel,oysters as the carrier,by EDTA titrimetric method,atomic absorption spectrometric method to study the particle size and effective composition medicine Fried out to the difficulty of the relationship,for Chinese medicine keel,oyster powder medicine don’t fry first to provide the evidence.Results:(1)the keel,oysters powder of superfine grinding process parameters optimization:into the ground before muffle furnace 500 ℃dry 2 hours,filling quantity is 200～350 g,medium filling rate to 60%～70%advisable,crushing temperature for 10 ℃～0 ℃-crushing time in 12 minutes respectively,eight minutes advisable.(2)the physics properties of the results of the study show that,keel,oysters after the superfine grinding,quality of a material tends to be even,liquidity reduce,specific surface area increases,increase solubility.(3)established the oysters,keel and superfine powder of the X ray diffraction a Fourier fingerprint standard fingerprint and characteristic peak markers.(4)the EDTA titrimetric method to 10 different origin keel,Chinese traditional medicine in content determination of calcium oysters and using atomic absorption spectrometry Zn,Cu,the Mn,Fe,Cd five content determination of trace elements,preliminary make keel,oysters calcium and trace elements in standard:keel,oysters calcium content limit for not less than 28%,respectively,35%;Zn,Cu,Mn,Fe,Cd five kinds of trace elements in limit for not less than 23.69,51.06;8.30,17.20;162.37,499.12;1092.37,4338.00;3.66,3.61 ug/g in order to better control the market on the quality of the keel,oyster.(5)traditional Chinese medicine keel,oysters after the superfine grinding decoction 10 min and the coarse crushing decoction after 60 min,the effective components of calcium and trace elements of Fried out much fewer,Chinese traditional medicine,oyster keel by superfine grinding medicine after first,Fried little sense,but does not need to perform "first Fried" this operation procedures.Conclusion:Keel,oysters after the superfine grinding,appearance characters,particle size distribution,solubility,and liquidity,produced different degree of change,but the chemical components without any obvious change;Traditional Chinese medicine keel,oysters after the superfine grinding medicine,first Fried little sense,but does not need to perform "first Fried" this operation procedures.So the traditional Chinese medicine of superfine grinding effects play has positive significance,proved the advantages of traditional Chinese medicine superfine powder.