| ObjectiveAtropine is currently the most effective drug for the control of juvenile myopia,but the long-term high frequency of eye side effects caused by the clinical use of atropine is limited,the purpose of this study to explore the intermittent use of 1%atropine ophthalmic gel for adolescent myopia prevention and treatment of effectivty land safety,in order to achieve the lowest frequency of use of myopia control method.MethodsCollected from July 2015 to January 2016 in the Fourth Affiliated Hospital of Kunming Medical University(Yunnan Second People’s Hospital)children ophthalmic outpatient clinic diagnosis of low myopia,and meet the inclusion criteria of 102 children,divided into A treatment group,the average age is 10.77±1.69 years old,13 males and 17 females,40 eyes(monocular or binocular myopia of-0.50DS or-0.75DS,atropine eye gel around the law,that is,the first week twice,the second week once,the third,four weeks off);The average age of the treatment group B is 10.97±1.67 years old,16 males and 14 females,60 eyes(binocular myopia,one month method,alternating eyes,point the right eye half a month after the left eye once,and so on);The average age of the treatment group C is 14.95± 0.83 years old,11 males and 9 females,40 eyes(binocular myopia,alternating eyes,point the right eye once a month after the left eye once,and so on);The average age of the group D is 10.64 ±1.73 years old,10 males,12 females,44 eyes(binocular myopia,fitting glasses);B,C,D group patients with binocular myopia ≥-1.00DS,≤-6.00 D,astigmatism ≤-11.00 D.A group of children in month after the observation of diopter,axial,visual acuity,changes in intraocular pressure.B,C group of children according to vision and symptoms given conventional optometry observation,all patients received a comprehensive eye examination before the test as a baseline standard,1 year after the observation of the group of diopter,axial,visual acuity,intraocular pressure changes,Compare the relevant data for statistical analysis.ResultsA group of 26 cases of 33 eyes completed the observation of treatment in a month,myopia after a month change(-0.16± 0.27)D,the increase of axial length was(0.002±0.26)mm;B,C,D groups were 64(85.00%)cases completed a l-year observation,of which B group of 26 cases of 52 cases,C group of 16 cases of 32 eyes,D group of 22 cases of 44 cases,of which B group of 26 cases of 52 cases,C group of 16 cases of 32 eyes,D group of 22 cases of 44 cases,after about a year observation,the myopia diopter progression in the group B,C and D was(-0.39±0.28)D,(-0.47±0.17)D and(-0.97±0.21)D.The axial growth was(0.14±0.08)mm,(0.19±0.12)mm and(-0.39 士 0.10)mm.The changes of refraction and axial length of group B and group D were significantly different(P<0.05).B group of children after atropine monocular near vision of 1.0 average 4.5 days,photophobia symptoms disappeared 4.4 days.All the subjects did not show significant increase in intraocular pressure.Conclusions1.Intermittent use of 1%atropine in the control of low myopia is effective.2.1%atropine intermittent eye drops in children without obvious near visual difficulties.3.1%intermittent use of atropine in children with no significant effect on intraocular pressure.4.Long-term intermittent use of 1%atropine children well tolerated,highly medical care,is the more appropriate mode of administration... |
PDF Full Text Request