The Polymorphisms Of Rs2619566 In CNTN4, Rs10260404 In DPP6 And Rs79609816 In INPP5B Are Closely Associated With Sporadic Amyotrophic Lateral Sclerosis From Han Ancestry Of Chinese Mainland

The pathogenesis about sporadic amyotrophic lateral sclerosis(sALS)hasn’t been known,the recent investigation suggested the genetic factors might play an important role.Therefore,this study aimed at searching some possible genetic factors for the pathogenesis and diagnosis of sALS.We conducted a genome-wide association study in 250 sALS and 250 controls from Han ancestry of Chinese mainland(HACM)and retrospectively analyzed the previously reported candidate loci related with the pathogenesis of sALS.27 of most possible associated candidate loci were chosen to further analyzed in an independent 239 sALS and 261 controls of HACM using sequenom MassARRAY and DNA sequencing.We discovered that rs2619566 in CNTN4,rs10260404 in DPP6 and rs79609816 in INPP5 B were closely associated with sALS from HACM.The subjects carrying the minor C allele of rs2619566 and the minor T allele of rs79609816 exhibited an increased risk of sALS,the carriers with the minor C allele of rs10260404 showed a decreased risk of sALS compared with the other genotype.Our study suggested that rs2619566 in CNTN4 gene,rs10260404 in DPP6 gene and rs79609816 in INPP5 B might play some roles in the pathogenesis of sALS,and provided genetically candidated evidences for diagnosing sALS.