The Change Of Advanced Ovarian Cancer CA125 Before And After Neoadjuvant Chemotherapy And The Satisfaction Of Tumor Reduction And The Prognosis Of Correlation Analysis

Objective: In this paper,through the observation of patients with clinical data who acceped interval dulking surgery after neoadjuvant chemotherapy,Study the changes of CA125 before and after neoadjuvant chemotherapy with the satisfaction of the tumor cells to destroy the loss,the relationship between the the survival time,In order to seek a certain for the diagnosis and treatment and prognosis of advanced ovarian cancer clinical basis.Methods: A retrospective analysis of the 1st affiliated hospital of medical college tumor by pelvic masses of department of gynaecology puncture pathology diagnosed with ovarian cancer parallel 1-2 cycle after neoadjuvant chemotherapy of tumor cells to destroy the loss any clinical data of 70 patients with advanced ovarian cancer,analysis of diagnosis and treatment for the first time CA125 values,CA125 decline rate after neoadjuvant chemotherapy,preoperative CA125 value and the satisfaction rate and prognosis of tumor cells to destroy the loss,Study CA125 decline rate after neoadjuvant chemotherapy and the satisfaction rate and prognosis of tumor cells to destroy the loss for correlation.Results: The T test and chi-square test suggest that one or two cycles after neoadjuvant chemotherapy,CA125 decline rate and preoperative CA125 level affect the satisfaction of patients reduced tumor.Preoperative CA125 acuities were 150u/ml and >150u/ml group of tumor satisfaction rate comparison,the difference was statistically significant(P<0.05),the survival rate,there was no statistically significant difference(P > 0.05).CA125 decline rate is 80% or higher and < 80% group of patient satisfaction and reduction of tumor,the difference was statistically significant(P<0.05),the survival rate,there was no statistically significant difference(P>0.05)。Conclusion: 1-2 cycle after neoadjuvant chemotherapy,preoperative CA125 and the decline rate of the CA125 levels can predict the net rate for patients with surgery,Preoperative serum CA125 is 150 u/ml or less and CA125 decline rate is 80% or greater reduction of tumor satisfaction can be used for preliminary judgment,but can’t predict the prognosis of patients.