Relationship Between LKB1 Gene Expression And Prognosis Of Non-small Cell Lung Cancer

Objective:To investigate the relationship between the expression of LKB1 and the prognosis of non-small-cell lung cancer.Methods: 23 cases of NSCLC patients were selected into the present study.All the patients came from the pathology department of Yijishan hospital from February,2015 to August,2016,as the lung cancer group.At the same time,we selected the normal lung tissue beside the cancer area as blank group.RT-PCR and western blotting was used to test the expression of the LKB1 gene.The relationship between the LKB1 and age,pathology type,clinical stage,size of the tumor,PFS were analyzed.Results: In the lung cancer group,the expressions of LKB1 mRNA and protein were relatively lower than the blank group(P<0.05).The expression level of LKB1 had no relationship with age,clinical stage,pathology type,size of the tumor(P>0.05),but had relationship with degree of differentiation.The patients expressing higher LKB1 m RNA had good prognosis,whose median survival was 13.033 months versus 5.267 months of those who had lower expressions of LKB1 m RNA.The progression free survival in the high expression group was(13.247 ±0.505)months versus(6.426 ±1.251)months in the low expression group,the difference was statistically significant(P<0.05).The high expression of LKB1 protein in patients with lung cancer group,the median survival time was 12.833 months versus 8.467 months of those who had lower expressions of LKB1,the progression free survival in the high expression group was(13.487 ± 1.079)months versus(8.239 ± 0.979)months in low expression group,the difference was statistical significance(P < 0.05).Conclusion:The expression of LKB1 in non-small cell lung cancer was significantly lower than that in adjacent tissues.The expression of LKB1 may relate to the degree of differentiation.A low expression of LKB1 m RNA and protein may prompt bad prognosis in NSCLC.