Value Of Apparent Diffusion Coefficient Values In Predicting Neoadjuvant Therapy Response Of Breast Invasive Ductal Carcinoma

Objective To predict the response of neoadjuvant therapy in breast invasive ductal carcinoma by using pretreatment apparent diffusion coefficient(ADC)values.Methods 81 of patients with breast invasive ductal carcinoma underwent DWI examination prior to neoadjuvant therapy.The neoadjuvant therapy effect were consist of tumor response and histological response.The patients were divided into the effective responder group(complete response,CR plus partial response,PR)and the non-effective responder group(stable disease,SD add progressive disease,PD)according to the tumor response of treatment,and also into major histological response(MHR)and non-major histological response(NMHR)according to the Miller & Payne system(MP).The binary logistic regression was performed to analyze the pretreatment ADC values between different groups.Age,T staging,regime of neoadjuvant therapeutic regimen and molecular subtyping also were evaluated.Results The pretreatment ADC value could predict neither the tumor response nor the MP grading after neoadjuvant therapy by univariate and multivariate analyses,with P=0.901 and P=0.115.But,molecular subtype and neoadjuvant therapeutic regimen were independent predictors for MHR of MP,with P=0.009 and P=0.050.Conclusion There wasn’t enough evidence that the pretreatment ADC value was a valuably quantitative parameter for predicting neoadjuvant therapy response in breast invasive ductal carcinoma.However,molecular subtype and neoadjuvant therapeutic regimen maybe can predict the MHR.