A Systematic Review Of Randomized Controlled Trials Of Acupuncture In The Treatment Of The Comorbidity Between Depression And Insomnia

Objective:Through the method of evidence-based medical system evaluation and meta-analysis,the therapeutic effect and safety of acupuncture in the treatment of depression and depression were evaluated by the previous literature,which provided evidence-based medical basis for clinical acupuncture treatment of depression and insomnia The At the same time,the design of randomized controlled trials of acupuncture and moxibustion for depressive disorder and the problems in methodology were discussed.The factors influencing the curative effect of acupuncture on the curative effect of depression and insomnia were preliminarily explored,and the quality of clinical research was improved.Acupuncture treatment of depression and insomnia comorbid randomized controlled trials of the program design,data analysis and evaluation of the study to provide reference.Methods:Based on the systematic review methodology provided by Cochrane,a scientific and effective search strategy was developed.All the literatures were searched and included in the standards-compliant study.Data were extracted,methodological quality evaluation and outcome indicators Report and discussion.Retrieval methods and screening methods:computer,manual and other methods of electronic databases and magazines in the journal literature,dissertations and gray literature to retrieve,computer search electronic database were Web of Science,Medline via Pubmed,Cochrane Library,Embase,(CBM),Weipu database(VIP),Wanfang database(WANFANG);manual search journals were "Chinese acupuncture","acupuncture","Chinese acupuncture and moxibustion","Chinese acupuncture and moxibustion","Chinese acupuncture and moxibustion" Research "," Journal of Acupuncture and Moxibustion "and" Shanghai Acupuncture and Moxibustion";In addition,through the scientific papers online and Open Gray to achieve gray literature or conference papers.The date of the search is from the building to December 30,2016.Finally,the use of EndNote X7 literature management software in addition to heavy,and secondly,according to the literature into the exclusion criteria,by reading the title,the summary of the content of the " And the full text,and finally selected to meet the inclusion criteria of the study.Data extraction and quality evaluation:data extraction and quality assessment of the data,both by the two evaluators independently completed,after the cross-check,such as judgments,can be discussed or third-party ruling,all data results in tabular form.We apply the risk of bias tool to the methodology of the incorporated literature research.Statistical analysis using RevMan 5.3 software and Stata14.0 software meta-analysis module.We do not only use the I2 statistic test,but also χ2 and its P-value test;report bias,if the number of documents included in more than 10,the production of funnel map to assess the risk of bias,due to visual In the data merging,when I2 is less than 50%,the fixed effect model is adopted,and when I2is the same,when I2 is less than 50%,the fixed effect model is used when I2 is less than 50%More than 50%,the use of random effects model.When I2is greater than 75%,the data will not be merged.(HAMD)or Depression Self-Rating Scale(SDS).The Pittsburgh Scale(PSQI)was used to evaluate the insomnia.The results showed that the patients were divided into two groups:the control group(P<0.05).Unlimited scale versions such as HAMD-17,HAMD-21 or HAMD-24.Results:Through the literature search,access to literature titles,summary of a total of 575,of which 418 English literature,157 Chinese literature.EndNote X7 software was used to extract the literature,and finally included in the literature 11,including two English literature,Chinese journal articles 9,a total of 906 cases of patients.Meta-analysis showed that most of the independent trials reported significant therapeutic effects,but the results of partial meta-analysis were heterogeneous,although multidisciplinary exploration of heterogeneity was carried out by subgroup analysis and susceptibility analysis Meta-analysis is difficult to find the exact heterogeneity of the source.Conclusion:1.Acupuncture is a positive and safe treatment for depression and insomnia.2.The study of randomised controlled trials of the common disease of depression and insomnia remains to be further standardized.