The Elinical Observation Of Transcutanclus Electrical Acupoint Stimulation On Perimenopausal Syndrome With Liver And Kidney Yin Deficiency

Objective This study was to observe and evaluate the clinical efficacy,safety and patient acceptance of transcutaneous electrical acupoint stimulation(TEAS)for the treatment of perimenopausal syndrome with liver and kidney yin deficiency by randomized controlled trial(RCT).Methods A total of 64 paticipants who met the inclusion criteria were randomly divided into perimenopausal syndrome group(TEAS group,32 cases)and electroacupuncture group(EA group,32 cases).The two groups selected the same acupoints as the bilateral Tianshu,Zigong,Sanyinjiao and Taixi.Participants of both groups were treated once every other day,3 times per week for 4 weeks.The modified Kupperman symptom score(KI),the Menopausal-Specific Quality of Life(MENQOL),serum E2,FSH,and the clinical efficacy were measured before and after treatment and 3 months follow-up,and to evaluate its safety,patients’ acceptance.Results(1)General data:There was no significant difference in age,course of disease and proportion of menopausal patients between the two groups(P>0.05).Patients’ basic situation was consistent and comparable.(2)Baseline comparion:There was no significant difference between the two groups in KI score,vasomotor symptom score(VSS),psychiatric symptom score(PSS),MENQOL score,and serum Estradiol(E2),Follicle-Stimulating Hormone(FSH)levels before the treatment(P>0.05).(3)Inner group comparison:There were significant differences in KI score;VSS,PSS,and MENQOL score compared before with after treatment,before and 3 months of followed up(P<0.05).In both groups,there were significant differences in the E2 level score between before and after treatment(P<0.05),but no significant difference between before and 3 months of followed-up(P>0.05).In the serum FSH level score,There was no significant difference between before and after treatment,before and 3 months of followed-up(P>0.05).(4)Inter group comparison:Differences of KI score,VSS,PSS,MENQOL score and serum E2,FSH after treatment and 3 months of followed-up were not obvious(P>0.05)in the two groups;There was no significant difference beteen two groups of total efficiency(P>0.05);There was a significant difference between the two groups in safety and patient acceptance(P<0.05).Conclusion Both groups could improve the clinical symptoms and the quality of survival in patients with perimenopausal syndrome;TEAS improved the clinical symptoms and the quality of life of patients with perimenopausal syndrome were no obvious difference compared with EA,and the follow-up result was also the same;Both TEAS and EA could improve the level of E2 in patients with perimenopausal syndrome,but the long-term effect was poor,and there was no significant improvement in the level of FSH in patients with perimenopausal syndrome;The safety and patients’ acceptance of TEAS was better than EA.