Optimization Of Oral Dosage Regimen For Ceftriaxone Base On PK/PD Theory

Objective:To perform Monte Carlo simulation of PK/PD with ceftriaxone and to optimize the clinical regimen.Method:The pharmacokinetic parameters of ceftriaxone in eight kinds of clinical commonpathogens were studied by using the method of dilution method.The pharmacokinetic parameters of ceftriaxone were evaluated by Monte Carlo simulation.Different dosing regimen.Results:The data of pharmacokinetic parameters such as T1/2,Vd,Cmax and AUC0-24 were obtained from three doses of ceftriaxone sodium high(3000mg)、medium(1500mg)、low(750mg).The MIC,MIC50,MIC90 and other pharmacodynamic parameters of eight pathogens were measured by concentration gradient method.The results showed that the CFR values(750mg,1500 mg,3000mg)of ceftriaxone for Enterobacter cloacae were measured at the interval of 6h using% f T> MIC≥50 as the target.The CFR of Streptococcus pneumoniae were 73.27%,82.91% and 91.10%,respectively.The CFR of Klebsiella pneumoniae were 89.28%,95.71% and 98.61%,respectively.The CFR of Acinetobacter were 83.96%,95.63% and 99.76%,respectively.The CFR values of Escherichia coli were 93.45%,99.87%and 98.20%,respectively.The CFR of Staphylococcus aureus were 60.65%,72.88% and 85.44%,respectively.With the use of %f T> MIC≥30 as the target,at the interval of 6h,the CFR values of Pseudomonas aeruginosa were 40.24%,59.91%,81.25%,respectively.Conclusion: Ceftriaxone in the clinical use of drug resistance,the sensitivity is gradually reduced.Therefore,clinical needs to be continuously monitored to determine the current resistance status of clinical bacteria to achieve effective microbial treatment.