Analysis Of The Cinical Characteristics In 112 Children With Immune Thrombocytopenia

Objective:To analyze the clinical characteristics and efficacy of immune thrombocytopenia(ITP)in children,and to analyze the diagnostic value of neutrophil to lymphocyte ratio(NLR)in children with ITP.Methods:ITP cases were collected from pediatric hospitalization in our hospital from January 2006 to October 2016.The clinical features were analyzed.Children with moderate to severe thrombocytopenia were divided into low dose group(1.2 g/kg)and high Dose group(2g/kg),both groups were combined with dexamethasone treatment,analysis of its efficacy.NLR was used as the control group in the same age group to analyze the diagnostic value of NLR in children with ITP.Results:112 cases of ITP in children age was from January to 14 years,the average age was 42.4 months,the age of onset<5 years old accounted for 76.8%,the age group male and female were no significant statistical difference.The incidence of winter and spring season is higher than that of summer and autumn(P<0.05).Forty-seven patients(70.5%)had a history of infection,42 cases(37.5%)had upper respiratory tract infection and 4 cases(3.5%)had intestinal infection;11 cases(9.82%)had a history of vaccination before the onset of the disease.Of all the cases,108 cases(96.4%)had glaucoma glaucoma,25 cases(22.3%)had oral mucosal bleeding,8 cases(7.1%)had epistaxis,4 cases(3.5%)had gingival bleeding,conjunctival hemorrhage and bloody stools all had 2 cases(1.8%),1 case(0.9%)had hematuria.There were significant differences in platelet count between the two groups after treatment,and there was no significant difference in the curative effect between the two groups.There was no significant difference in NLR(0.75±0.59)between children with ITP and NLR(0.76±0.36)in normal subjects.Conclusion:1.ITP children are mostly in the spring and winter,before the onset of upper respiratory tract infection history.There is no significant difference in the incidence of men and women,children are mostly within 5 years of age.2.Most of the children with ITP onset of platelet count<30×109/L,the clinical manifestations of skin and mucous membrane bleeding.3.There is no significant difference in the short-term efficacy of low-dose and high-dose gamma globulin regimens.4.The neutrophils to lymphocytes ratio has no reference for the diagnosis of ITP children.