Effects Of Remote Ischemic Preconditioning On Acute Myocardial Injury In Patients Undergoing Valve Replacement

Objective:This study investigated the effects of remote ischemic preconditioning(RIPC)on acute myocardial injury and clinical outcome in Non-severe adult patients undergoing valve replacement surgery.Methods:Eighty Non-severe adult patients scheduled for elective valve replacement undergoing cardiopulmonary bypass(CPB)were randomly assigned to control or remote ischemic preconditioning treatment.RIPC was applied beginning with the first surgical incision by three times of inflating the cuff to 200 mm Hg for 5 min,followed by 5 min of deflation.The plasma creatine kinase-MB(CK-MB)and cardiac troponin I(c Tn I)were determined Within the prescribed time.The preoperative,intraoperative,and postoperative characteristics,and hemodynamics values were recorded during the study.Results:There were no significant differences in patient preoperative,intraoperative,and postoperative characteristics and hemodynamics values between groups(P>0.05).The activity of CK-MB and c Tn I was significantly lower in RIPC group than CON group at 4 h,24 h,and 48 h after aortic unclamping(P<0.05).Conclusions:The present study demonstrated that remote ischemic preconditioning might reduce release of CK-MB and c Tn I in patients undergoing valve replacement.However,RIPC does not improve the short-term clinical outcome of these patients.