Clinical Observation On Treatment For Liver-Depression-Kidney-Deficiency-Type Hyperprolactinemia Irregnlar Menstruation By Soothing Liver Tonifying Kidney Method

Objective:To observe the clinical curative effect of treatment for patients with liver-depression-kidney-deficiency-type hyperprolactinemia(HPRL)irregular menstruation by soothing-liver-tonifying kidney method,and to seek the effective treatment method for hyperprolactinemia and summarize the clinical experience of the tutor.Methods:60 patients with hyperprolactinemia(HPRL)irregular menstruation were collected and randomly divided into Treatment Group and Control Group by the clinic sequence(30 cases for each).The Treatment Group was treated with traditional Chinese medicine(by soothing-liver-tonifying kidney method),while the Control Group was treated with Bromocriptine Mesylate.We followed up and filled in the clinical observation table,recorded the patients’ prolactin(PRL)levels,menstruation and related clinical symptoms,BBT type and relapse rate after treatment,and utilized statistical analysis to observe the clinical curative effect of treatment for patients with liver-depression-kidney-deficiency-type hyperprolactinemia irregular menstruation.Results:1.There was no statistically significant difference in age,TCM symptom score,menstrual disorder symptom,PRL level and BBT type between the two groups before treatment(P>0.05).2.The total effective rate was 93.3%in the Treatment Group and 76.7%in the Control Group.There was statistically significant difference between the two groups(P<0.05).3.Regarding to the treatment of hypomenorrhea,the difference was statistically significant(P<0.05),and the Treatment Group was better than the Control Group.In term of recovery of patients’ menstrual cycles,the curative effect of two groups were equal;regarding to the treatment of scanty menstruation,The curative effect of the Treatment Group was better than that of the Control Group.4.Regarding to improving the TCM symptom,the curative effect of the Treatment Group is better than that of Control Group,and comparison difference between groups was statistically significant(P<0.05).5.There was statistically significant difference between the two groups in PRL values both before and after treatment(P<0.05);There was no statistically significant difference between the two groups after treatment(P>0.05).Both groups could effectively reduce the PRL,with equal curative effect.6.There was statistically significant difference between the two groups in BBT before and after treatment(P<0.05).There was no statistically significant difference between the two groups in BBT after treatment(P<0.05).The curative effect of the Treatment Group was better than that of the Control Group.7.According to a follow-up after stopping drugs for 2 months,there was no statistically significant difference in the PRL level and menstrual cycle between in the Treatment Group and that at the end of the treatment(P>0.05),while there was statistically significant difference in the PRL level and menstrual cycle between in the Control Group and that at the end of the treatment.8.During the medication,there was no adverse reaction occurred on patients in the Treatment Group,while there were varying degrees of nausea,dizziness,fatigue,drowsiness,constipation and other adverse reactions on some patients in the Control Group,but they all could adhere to medication.9.Safety analysis:During treatment,the bloods,urines,fecal routines,liver and kidney functions,ECGs of patients in both two groups were normal,and the treatment methods of both two groups were safe.Conclusion:The results of the study show that treatment for patients with liver-depression-kidney-deficiency-type hyperprolactinemia irregular menstruation by soothing-liver-tonifying kidney method,not only can effectively reduce the patient’s prolactin levels,but also effectively improve the clinical symptoms,restore ovulation function,with low recurrence rate after stopping drugs,without any adverse reactions.