| 1 Objective To observe IBS-SSS,integral of TCM syndromes,SAS,SDS scale scores and evaluate the clinical efficacy before and after treatment and follow-up one month after the changes of using Wen Shen Jian Pi soup to spleen yang deficiency and kidney yang deficiency type irritable bowel syndrome with diarrhea(IBS-D).2 Method Select 60 patients of IBS-D and randomly divide them to two groups: every group has30 patients,control group was treated by the Wen Shen Jian Pi soup and another was treated by Pi Wei Xiu An and Shuang Qi Gan Jun Si Lian Huo Jun Pian,4weeks treatment,followed up for 1 month.Observe two groups of patients before and after treatment and follow-up 1 month when the IBS-SSS,integral of TCM syndromes,SAS,SDS score and clinical safety index changes.3 Results3.1The integral of TCM syndrome:On the total score of syndromes,the clinical effect and long-term efficacy of treatment group were significantly better than that of control(P<0.01).On the single TCM syndrome integral,the treatment group diarrhea,cold limbs,lumbar debility,loss of appetite and fatigue symptom in the clinical effect and is superior to the control group(P<0.05 or P<0.01).The treatment group improve abdominal distension was significantly better than the control group(P<0.01),but the long-term curative effect had no difference(P>0.05).Abdominal pain in patients with two groups were significantly improve(P<0.01),But no difference between groups(P>0.05).3.2IBS-SSS integral:Two groups after treatment in patients and followed-up for one month with IBS-SSS interal were improved(P<0.05 or P<0.01),and the clinical effect and long-term efficacy of treatment group were significantly better than that of control group(P<0.05).3.3SAS,SDS scores:Two groups of patients at the end of treatment,SAS integral were improve(P<0.05).Followed up for one month,the control group SAS points from the previous slightly improve,but there is no statistical significance(P>0.05).Two groups of patients after the treatment and follow-up one month when SDS score Than before improvement(P<0.05 or P<0.01),and in terms of improvement of SAS,SDS score,to improve the situation and the long term curative effect in treatment group were better than control group(P<0.05 or P<0.01).3.4The curative effect of TCM syndrome:At the end of 4 weeks treatment,the treatment group effective rate was 93.3% of syndromes,the control group was76.7%,the treatment group in improving syndromes curative effect for patients with IBS-D is better than that of control group(P<0.05).Followed up for 1month,TCM syndrome in treatment group effectiveness 90.0%,control group was 66.7%,th treatment group is better than that of control group(P<0.05).3.5 Safety of medication:Treatment and followed-up period,the treatment group and control group safety indexes of two groups of patients were not seen obvious abnormity,no adverse reaction report.4 Conclusions4.1The Wen Shen Jian Pi soup to spleen yang deficiency and kidney yang deficiency type IBS-D of TCM syndrome integral,curative effect is better than the control group.The treatment group in improving the cold diarrhea,and cold limbs,lumbar debility,loss of appetite,languid long curative effect in the clinical effect and is superior to control group;treatment group improve abdominal distension condition is better than that of control group,but the long-term curative effect is no statistical difference.Both groups can significantly improve patients with abdominal pain,and curative effect.4.2The Wen Shen Jian Pi soup can dramatically improve the IBS-D patients with IBS-SSS integral,and the long-term curative effect is better.4.3The treatment group and control group all can improve IBS-D anxiety and depression symptoms,treatment group curative effect is better than the control group.4.4Treatment group total effective rate was higher than the control group of syndromes,the difference was statistically significant.4.5The kidney and spleen side has a good drug safety. |
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