Effect Of Anxiety/Depression On High Sensitivity C-reactive Protein In Patients With Coronary Heart Disease Before And After PCI

Objective: To investigate the effect and clinical significance of anxiety/ depression on High Sensitivity C-reactive Protein in patients with Coronary Heart Diseasebefore and after being treated with PCI.Methods: From March to December 2016,a total of71 patients who was diagnosed by CAG and treated as coronary heart disease from the Department of Cardiology at the First Hospital of Jilin University.Psychological conditions of patients were evaluated by two independent researchers based on Hamilton Anxiety Scale(HAMA)and the Hamilton Depression Scale(HAIL).After a consensus was reached,all the subjects were divided into groups of PCI with anxiety/depression and PCI with non-anxiety/depression.Patients who were performed by CAG with no PCI were divided into control group.The serum high sensitivity C-reactive proteinwas determined by peripheral venous blood of all the subjects,acquired pre-operation and the first day afteroperation with an empty stomach.Comparison was made concerning the serum high sensitivity C-reactive proteinbetween pre-and post-operation.Results:(1)Pre-operation: There was a significant difference concerning the level of Hs-CRPamong three groups(P<0.05).After pairwise comparison,a significantly higher level of Hs-CRPin the group of PCI with anxiety/depressioncompared with PCI with non-anxiety/depressionand control group was detected(P<0.05).The difference between PCI with non-anxiety/depression and control group was of no statistical significance.(2)Post-operation: There was a significant difference regardingthe level of Hs-CRP among three groups(P<0.05).After pairwise comparison,a significantly higher level of Hs-CRP in the group of PCI with anxiety/depression than that of PCI with non-anxiety/depressionand control group was detected(P<0.05),and the level of Hs-CRP was significantly higher than that of control group(P<0.05).(3)Comparison between pre-and post-operation: the level of Hs-CRP was determined as 7.760±1.850mg/Land4.909±1.076mg/L in group of PCI with anxiety/depression and PCI with non-anxiety/depression,respectively,both significantly higher than that of pre-operation(3.786±1.473mg/L;2.054±0.950mg/L).There was no statistical significance was noticed in control group.Conclusion:(1)Pre-operation: Asignificantly higher level of Hs-CRP in group of PCI with anxiety/depressioncompared withgroup of PCI with non-anxiety/depressionand control group was found,indicating that there was a close correlation between anxiety/depressionand the level of Hs-CRP.The inflammation reactionin patients suffered from CHD with anxiety/depressionmay be manifested more obviously.(2)Post-operation: A significantly higher level of HS-CRP in group of PCI compared with control group indicated that inflammation may be triggered and exacerbated in a short time after receiving PCI for those patients with CHD.(3)Comparison between pre-and post-operation:A significantly higher level of HS-CRP in group of PCI with anxiety/ depression compared with group of PCI with non-anxiety/ depression indicated that anxiety/ depression condition may exacerbateinflammation reaction for those patients received PCI.