Detection And Clinical Significance Of Serum Iron And Serum Ferritin In The Patients With Lung Cancer

Objective:Iron is one of the important trace elements involved in the multiple metabolism process of human body.The transformation of iron between the two valence states will produce reactive oxygen species,which is associated with the development of tumors.More and more experiments and cohort studies found that trace element iron was closely related to carcinogenesis and tumor development.The relationships between trace element iron and carcinogenesis as well as tumor development have not concluded in research at home and abroad.The purpose of this study is to explore the change levels and influencing factors of serum iron and serum ferritin in patients with lung cancer.Methods:A retrospective study of newly diagnosed primary lung cancer patients confirmed by histology or cytology in Cancer Center,First Hospital,Jilin University during the period January 2011 to December 2014,including 150 patients with non-small cell lung cancer or small cell lung cancer,was performed.As contrast,150 healthy persons were collected in medical examination center from January 2011 to December 2012.3-5 ml peripheral venous blood was drawn from each patient at the time of initial diagnosis,100 μl serum samples were separated in the EP tube after centrifugation,the serum was placed in refrigerator at-80℃ for preservation.Serum iron levels were measured by inductively coupled plasma atomic emission spectrometry,serum ferritin levels were measured by electro-chemiluminescence immunoassay.Then we collected the clinical data of each patient,including gender,age,smoking history,family history,pathological type,tumor stage,CRP,etc.Comparison of serum iron and serum ferritin levels between lung cancer group and healthy group was conducted by rank sum test.The correlations between the levels of serum iron,serum ferritin and CRP were analyzed by spearman rank correlation.Results:1.Serum ferritin levels in lung cancer patients were significantly higher than those in healthy,and there was no significant difference in serum iron levels.Further results indicated that serum iron levels in the patients with limited-stage small cell lung cancer were higher than those in healthy.Serum iron levels in the patients with extensive small cell lung cancer were lower than those in healthy.2.Serum iron levels in the patients with extensive small cell lung cancer were lower than those with limited-stage small cell lung cancer.The levels of serum ferritin and CRP were higher in the patients with extensive small cell lung cancer than those with limited stage small cell lung cancer.3.Serum iron levels in the non-small cell lung cancer patients at stage IV were lower than those at stage I~III,Serum ferritin levels in the non-small cell lung cancer patients at stage IV were higher than those at stage I~III.4.62.2% lung cancer patients had elevated CRP levels,there was a negative correlation between the levels of serum iron and CRP,the correlation coefficient was-0.321.Serum ferritin levels were positively correlated with CRP,the correlation coefficient was 0.462.Conclusions:1.Advanced lung cancer patients had lower serum iron levels and higher serum ferritin levels.Serum iron and serum ferritin levels may be related to the prognosis of patients with lung cancer.2.The levels of serum iron and serum ferritin in patients with lung cancer were dynamic,and inflammation was probably an important factor involved in the regulation of iron metabolism.