Analysis Of Clinical Characteristics Of Cervical Adenocarcinoma

Objective : This article collects and analyzes 365 patients with cervical adenocarcinoma from Jan.1996 to Dec.2015 in No.2 hospital of Jilin University.Investigate the clinical and pathological characteristics,and further analysis of prognostic factors.Method: Retrospective analysis the 365 cases of cervical adenocarcinoma in patients with clinical follow-up data.Analyze and summarize the prognostic factors.Create tables and record the clinical and pathological features of the cases with EXCEL software firstly.The data were statistically analysised by SPSS 19.0 ststistical software.Difference was statistically significant(p<0.05).Results: The incidence of cervical adenocarcinoma is mainly 46-50 years old,and there was no significant difference in age between different ages(p<0.05).There was no obvious trend of younger.The detection rate of TCT was about 65.6%,while the HPV-DNA was about 64.4%.The positive rate of TCT combined with HPV-DNA could be as high as 85.11%.The overall 3-year survival rate and the 5-year survival rate of patients with cervical adenocarcinoma were 90.8% and 65.5%,while the average survival time was 118.858±7.122 month.The overall 3-year progression free survival rate and the 5-year progression free survival rate were 83.4% and 47.7%,while the average progression free survival was about 87.095±6.308 months.Univariate analysis suggests that FIGO stage,pathological types,depth of myometrial invasion,intravascular tumor thrombus invasion,lymph node metastasis and ovarian metastasis had significant difference in the survival of cervical adenocarcinoma(p<0.05).There was no significant difference in survival and recurrence of neoadjuvant chemotherapy.Multivariate analysis suggests that only FIGO stage and pathological types was the indepentedt prognostic factors of cervical adenocarcinoma.Conclusions:1.The incidence of cervical adenocarcinoma is mainly in the age of 46-50 years old,and there was no significant difference between different ages.There was no obvious trend of younger.2.Only TCT or HPV-DNA detection was less sensitive to screening for cervical adenocarcinoma while the combination of the two methods can effectively increase the detection rate.And the endocervical curettage and LEEP shoule be used timely.3.For young women in early stage,it is possible to preserve the ovaries to relieved the symptoms of hormone deficiency.4.Neoadjuvant chemotherapy for patients with stage Ⅰ B2-Ⅱ A2 had no significant difference in the survival rate,compared to the cases with the same period of the cervical adenocarcinoma.5.Management of patients with cervical adenocarcinoma with high risk factors should be strengthened,and the individualized treatment plan will be urgently needed.