| Objective:This study aims to observe the clinical efficacy about the treatment of postherpetic neuralgia(PHN)by the Qinglongbaiwei method and the changes of serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels in peripheral blood before and after treatment,which is order to provides a certain clinical basis for the treatment of PHN.Methods:All cases were from the outpatient and inpatient of Acupuncture and Dermatology of Wuhan First Hospital,which was diagnosed as PHN patients.The patients were randomly divided into treatment group(Qinglongbaiwei group)and control group(common acupuncture group).Each grouphad33 cases.There were 66 cases in total.Thetreatmentgroup and controlgroup respectively has1 case that did not adhere totreatment due to special circumstances and removed,so the final observed in the control group and treatment group each32 patients.To observe the clinical efficacy of Qinglongbaiweimethod on the treatment of PHNand thecomprehensive efficacy,VAS score,analgesic effect,serum IL-6 and TNF-α concentrationschangeswere statisticallyanalyzed before and aftertreatment.Results:(1)Comparison of therapeutic effects,the treatment group cured 12 cases(37.50%),markedly effective in 14 cases(43.75%),effective in 2 cases(6.25%),invalid in 4 cases(12.5%),the total effective rate 87.5%;the control group cured 6 cases(18.75%),markedly effective in 8 cases(25.00%),effective in 5 cases(15.63%),invalid in 13 cases(40.63%),the total effective rate 59.37%.According to the statistical analysis,the treatment groupachieved a better overall efficacythanthe control group(P<0.05).(2)There was no significant difference in VAS score between the two groups before the first treatment(P>0.05).The VAS pain scores of the two groups were better than those before treatment and the difference was statistically significant(P<0.05).Aftertreatment,the treatment group was superior to the control group and the difference was statistically significant(P<0.05).(3)The analgesic effect of the two groups was significantly better than that of the control group and the difference was statistically significant(P<0.05).(4)There was no significant difference in the HAMD scores between the two groups before treatment(P> 0.05).Aftertreatment,the HAMDscores of the two groups were lower than those before treatment and the difference was statistically significant(P<0.05).Aftertreatment,the HAMD scores of the treatment group was lowerthan the control group and the difference was statistically significant(P<0.05).(5)There was no significant difference in the serum IL-6level between the two groups before treatment(P> 0.05).After treatment,the serum IL-6levelof the two groups were lower than those before treatment and the difference was statistically significant(P<0.05).After treatment,the serum IL-6levelof the treatment group was lower than the control group and the difference was statistically significant(P<0.05).(6)There was no significant difference in the serum TNF-αlevel between the two groups before treatment(P> 0.05).After treatment,the TNF-αlevelof the two groups were lower than those before treatment and the difference was statistically significant(P<0.05).After treatment,the TNF-αlevelof the treatment group was lower than the control group and the difference was statistically significant(P<0.05).(7)Safety evaluation,the two groups of patients in the course of treatment were not more obvious infection,systemic reactions and other side effects.It is suggested that the treatment of PHN is moresafe.Conclusion:Forthe treatment of PHN,Qinglongbaiwei method is superior to conventional acupuncture therapy.It can not only significantly reduce the serum TNF-α and IL-6 concentration,and reduce the PHN neuropathic symptoms,and has a better analgesic effect,but also can improve the mental state of anxiety and depression in patients.Qinglongbaiwei method is an ancient therapy.This methodis a safe and effective treatment,with no side effects.It deserves to be popularized and used clinically. |
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